P11
- CAS No.
- 848644-86-0
- Chemical Name:
- P11
- Synonyms
- P11 ( (trifluoroacetate salt);L-Lysinamide, L-histidyl-L-seryl-L-α-aspartyl-L-valyl-L-histidyl- (9CI)
- CBNumber:
- CB04796587
- Molecular Formula:
- C30H48N12O9
- Molecular Weight:
- 720.79
- MDL Number:
- MOL File:
- 848644-86-0.mol
| Boiling point | 1380.0±65.0 °C(Predicted) |
|---|---|
| Density | 1.381±0.06 g/cm3(Predicted) |
| storage temp. | -20°C, protect from light |
| solubility | Soluble to 1 mg/ml in 20% acetonitrile - 0.1% acetic acid |
| form | Powder |
| pka | 4.17±0.10(Predicted) |
| color | White to off-white |
| Sequence | H-His-Ser-Asp-Val-His-Lys-NH2 |
P11 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | P999043 | P11 | 848644-86-0 | 1mg | $80 | 2021-12-16 | Buy |
| ApexBio Technology | B5699 | P11 | 848644-86-0 | 1mg | $125 | 2021-12-16 | Buy |
| ChemScene | CS-0028921 | HSDVHK-NH2 99.63% | 848644-86-0 | 5mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-0028921 | HSDVHK-NH2 99.63% | 848644-86-0 | 10mg | $310 | 2021-12-16 | Buy |
P11 Chemical Properties,Uses,Production
Uses
P11 is a useful building block in the synthesis of various pharmaceuticals
Enzyme inhibitor
This potent PDZ motif-containing anti-angiogenic agent (FW = 720.78 g/mol; CAS 848644-86-0; Sequence: HSDVHK-NH2) targets the integrin αvβ3-vitronectin interaction, blocking proliferation and inducing apoptosis in human vascular endothelial cells (HUVECs). Arg-Gly-Asp (or RGD) binding-site recognition by P11 is site-specific, showing a strong antagonism against αvβ3-vitronectin interaction, IC50 = 26 nM. The binding orientation of docked P11 in αvβ3 is similar to that for RGD, suggesting a divalent metal-ion coordination is a common driving force for the formation of both SDV·αvβ3 and RGD·αvβ3 complexes. P11 appears to inhibit b-Fibroblast Growth Factor (or bFGF) -induced HUVEC proliferation via mitogen-activated protein kinase kinase and extracellular- signal regulated kinase inhibition as well as p53-mediated apoptosis related with activation of caspases. (Note: Consisting of 80-90 amino-acids in far-flung signaling proteins and binding to short C-terminal regions in protein interaction partners, “PDZ” is an acronym that includes the first letters of Post-synaptic density protein (PSD95), Drosophila Dlg1 tumor suppressor, and Zonula occludens-1 protein (zo-1), the first proteins discovered to share this domain.)
P11 Preparation Products And Raw materials
Raw materials
Preparation Products
P11 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10311 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Zhejiang Hangyu API Co., Ltd | +8617531972939 | anna@api-made.com | China | 2944 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Creative Peptides | info@creative-peptides.com | United States | 6084 | 56 | |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29786 | 68 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 +86-17380623303 | Caroline@youngshechem.com | China | 4860 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | Eric@peptidego.com | China | 6756 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Hangzhou Go Top Peptide Biotech | 0571-88211921 13355716090 | Sales@gotopbio.com | China | 2851 | 58 |