P11

P11 C화학적 특성, 용도, 생산

용도

P11 is a useful building block in the synthesis of various pharmaceuticals

효소 저해제

This potent PDZ motif-containing anti-angiogenic agent (FW = 720.78 g/mol; CAS 848644-86-0; Sequence: HSDVHK-NH2) targets the integrin αvβ3-vitronectin interaction, blocking proliferation and inducing apoptosis in human vascular endothelial cells (HUVECs). Arg-Gly-Asp (or RGD) binding-site recognition by P11 is site-specific, showing a strong antagonism against αvβ3-vitronectin interaction, IC50 = 26 nM. The binding orientation of docked P11 in αvβ3 is similar to that for RGD, suggesting a divalent metal-ion coordination is a common driving force for the formation of both SDV·αvβ3 and RGD·αvβ3 complexes. P11 appears to inhibit b-Fibroblast Growth Factor (or bFGF) -induced HUVEC proliferation via mitogen-activated protein kinase kinase and extracellular- signal regulated kinase inhibition as well as p53-mediated apoptosis related with activation of caspases. (Note: Consisting of 80-90 amino-acids in far-flung signaling proteins and binding to short C-terminal regions in protein interaction partners, “PDZ” is an acronym that includes the first letters of Post-synaptic density protein (PSD95), Drosophila Dlg1 tumor suppressor, and Zonula occludens-1 protein (zo-1), the first proteins discovered to share this domain.)

P11 준비 용품 및 원자재

원자재

준비 용품

P11 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10312	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19743	58
Zhejiang Hangyu API Co., Ltd	+8617531972939	anna@api-made.com	China	2944	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Creative Peptides		info@creative-peptides.com	United States	6084	56
Beijing Solarbio Science & Tecnology Co., Ltd.	010-50973130 4009686088	3193328036@qq.com	China	29786	68
Chengdu Youngshe Chemical Co., Ltd.	+86-17380623303 +86-17380623303	Caroline@youngshechem.com	China	4905	58
Hangzhou Peptidego Biotech Co.,Ltd.	0571-87213919	eric@peptidego.com	China	6526	58
BOC Sciences	--	info@bocsci.com	USA	0	65
Hangzhou Go Top Peptide Biotech	0571-88211921 13355716090	Sales@gotopbio.com	China	2843	58