2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺
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- CAS号:
- 223104-29-8
- 英文名:
- SEA-0400
- 英文别名:
- CS-1043;SEA-0400;SEA 0400; SEA-0400;SEA0400 >=98% (HPLC);SEA 0400; SEA-0400;SEA0400;2-(4-((2,5-DIFLUOROBENZYL)OXY)PHENOXY)-5-ETHOXYANILINE;2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline;2-[4-[(2,5-Difluorophenyl)methoxy]phenoxy]-5-ethoxybenzenamine;BenzenaMine, 2-[4-[(2,5-difluorophenyl)Methoxy]phenoxy]-5-ethoxy-
- 中文名:
- 2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺
- 中文别名:
- SEA0400游离态;NA+-CA2+EXCHANGER抑制剂(SEA0400);2-(4-((2,5-二氟苄基)氧基)苯氧基)-5-乙氧基苯胺;2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺
- CBNumber:
- CB12570386
- 分子式:
- C21H19F2NO3
- 分子量:
- 371.38
- MOL File:
- 223104-29-8.mol
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2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺化学性质
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沸点:
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485.0±45.0 °C(Predicted)
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密度:
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1.254±0.06 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
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溶解度:
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insoluble in H2O; ≥18.57 mg/mL in DMSO; ≥46.4 mg/mL in EtOH with ultrasonic
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形态:
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solid
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酸度系数(pKa):
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4.04±0.10(Predicted)
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颜色:
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White to khaki
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2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺性质、用途与生产工艺
SEA0400 是一种选择性的 Na+-Ca2+ exchanger (NCX) 的强效抑制剂，可抑制神经细胞、星形胶质细胞和小胶质细胞中Na+依赖性的Ca2+吸收，对应的IC50值分别为33 nM、5.0 nM和8.3 nM。SEA0400 可防止硝普钠 (SNP) 提高 ERK 和 p38 MAPK 的磷酸化和通过细胞外Ca2+依赖的方式增强reactive oxygen species (ROS) 的产生。
| Target | Value |
p38 MAPK
()
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ERK
()
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ROS
()
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NCX
(in cultured astrocytes)
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5.0 nM
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NCX
(in cultured microglia)
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8.3 nM
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SEA0400 inhibits Na
+
-dependent
45
Ca
2+
uptake in cultured neurons, astrocytes, and microglia. IC
50
values of SEA0400 are 33 nM (neurons), 5.0 nM (astrocytes), and 8.3 nM (microglia). SEA0400 prevents sodium nitroprusside (SNP) to increase ERK and p38 MAPK phosphorylation, and production of reactive oxygen species (ROS) in an extracellular Ca
2+
-dependent manner.
SEA0400 (3 mg/kg + 3 mg/kg/h for 2 h, i.v.) attenuates the infarct volume in the cerebral cortex and striatum, does not affect the mean the regional cortical blood flow in anesthetized rats. SEA0400 protects against the dopaminergic neurotoxicity (determined by dopamine levels in the midbrain and striatum, tyrosine hydroxylase immunoreactivity in the substantia nigra and striatum, striatal dopamine release, and motor deficits) in MPTP-treated C57BL/6J mice.
2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-15515 | SEA0400 | | 1 mg | 589元 |
| 2024/04/30 | HY-15515 | 2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺
SEA0400 | 223104-29-8 | 5mg | 1400元 |
2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺
生产厂家
223104-29-8, 2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺 相关搜索:
- 天然产物
- 细胞生物学试剂
- 膜转运/离子通道
- 抑制剂
- C21H19F2NO3
- 2-(4-((2,5-二氟苄基)氧基)苯氧基)-5-乙氧基苯胺
- SEA0400游离态
- NA+-CA2+EXCHANGER抑制剂(SEA0400)
- 2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺
- 223104-29-8
- SEA0400 >=98% (HPLC)
- SEA 0400; SEA-0400;SEA0400
- CS-1043
- SEA 0400; SEA-0400
- 2-(4-((2,5-DIFLUOROBENZYL)OXY)PHENOXY)-5-ETHOXYANILINE
- 2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline
- 2-[4-[(2,5-Difluorophenyl)methoxy]phenoxy]-5-ethoxybenzenamine
- BenzenaMine, 2-[4-[(2,5-difluorophenyl)Methoxy]phenoxy]-5-ethoxy-
- SEA-0400