7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇
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- CAS号:
- 440122-66-7
- 英文名:
- 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
- 英文别名:
- WAY 200070;WAY200070;WAY 200070;7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol;5-Benzoxazolol, 7-bromo-2-(4-hydroxyphenyl)-;7-Bromo-2-(4-hydroxyphenyl)benzo[d]oxazol-5-ol;7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol;Estrogen Receptor/ERR,WAY200070,WAY-200070,Inhibitor,inhibit
- 中文名:
- 7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇
- 中文别名:
- 化合物WAY 200070;WAY 200070,ERΒ激动剂;7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇
- CBNumber:
- CB22518907
- 分子式:
- C13H8BrNO3
- 分子量:
- 306.11
- MOL File:
- 440122-66-7.mol
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7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇化学性质
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沸点:
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463.6±35.0 °C(Predicted)
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密度:
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1.720±0.06 g/cm3(Predicted)
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储存条件:
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Store at RT
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溶解度:
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DMSO: ≥20mg/mL
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形态:
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solid
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酸度系数(pKa):
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7.26±0.40(Predicted)
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颜色:
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White to off-white
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7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇性质、用途与生产工艺
WAY-200070是选择性的雌激素受体激动剂，IC50值为2.3 nM。
IC50: 2.3 nM (ERRβ), 155 nM (ERRα)
Administration of WAY-200070 (30 mg/kg s.c.) causes nuclear translocation of ERRβ receptors in WT mice. Administration of WAY-200070 (30 mg/kg s.c.) produces a delayed 50% increase in dopamine in the striatum of wild type mice. WAY-200070 (30 mg/kg s.c.) reduces immobility time in the mouse tail suspension test indicating an antidepressant-like effect. In gonadally intact male and female mice WAY-200070 increases agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected. Ovariectomized (ovx) mice treated with PPT fail to learn the socially acquired preference, while WAY-200070-treated ovx mice shows a two-fold prolonged preference for the food eaten by their demonstrator. WAY-200070, shows significantly decreased anxiety-like behaviors in both the open-field and elevated plus maze and significantly less depressive-like behaviors in the forced swim test.
7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-101271 | WAY-200070 | | 1 mg | 400元 |
| 2024/11/08 | HY-101271 | 7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇
WAY-200070 | 440122-66-7 | 5mg | 880元 |
7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇
生产厂家
440122-66-7, 7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇 相关搜索:
- 抑制剂
- 合成有机化合物配体
- 原料
- WAY 200070,ERΒ激动剂
- 7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇
- 化合物WAY 200070
- 440122-66-7
- Estrogen Receptor/ERR,WAY200070,WAY-200070,Inhibitor,inhibit
- 7-Bromo-2-(4-hydroxyphenyl)benzo[d]oxazol-5-ol
- 5-Benzoxazolol, 7-bromo-2-(4-hydroxyphenyl)-
- WAY200070;WAY 200070
- 7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol
- WAY 200070
- 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol