MAY-262611
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- CAS号:
- 1123231-07-1
- 英文名:
- MAY-262611
- 英文别名:
- DKK1;CS-1296;MAY-262611;WAY-262611;Wnt/β-catenin;Dickkopf-1，DKK-1;WAY262611; WAY 262611;Human DKK1 Protein, His Tag;Recombinant Mouse Dkk-1 Protein, 8*His Tag;Recombinant Human DKK-1/DKK1 Protein, 8* His Tag
- 中文名:
- MAY-262611
- 中文别名:
- WAY-262611游离态;Β-联蛋白激动剂(WAY-262611);1-[4-(2-萘基)-2-嘧啶基]-4-哌啶甲胺;(1-(4-(萘-2-基)嘧啶-2-基)哌啶-4-基)甲胺;ANTI-DKK1 ANTIBODY-抑癌蛋白DKK1抗体;抗体:MOUSE DKK1 ANTIBODY (MOR04454) RMB48101
- CBNumber:
- CB32628072
- 分子式:
- C20H22N4
- 分子量:
- 318.42
- MOL File:
- 1123231-07-1.mol
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MAY-262611化学性质
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沸点:
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544.8±42.0 °C(Predicted)
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密度:
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1.169±0.06 g/cm3(Predicted)
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储存条件:
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under inert gas (nitrogen or Argon) at 2–8 °C
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溶解度:
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DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
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形态:
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Powder
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酸度系数(pKa):
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10.13±0.29(Predicted)
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颜色:
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Light yellow to yellow
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MAY-262611性质、用途与生产工艺
WAY-262611是 Wnt/β- 联蛋白激动剂，可增加骨形成速率，在 TCF- 荧光素酶测定实验中的 EC50 值为0.63 μM。WAY-262611 也是 Dkk1 的抑制剂。
EC50: 0.63 μM (β-Catenin)
WAY-262611 has the most potent activity in the primary assay, low kinase inhibition potential, and high solubility.
WAY-262611 has excellent pharmacokinetic properties and shows a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration. Calvariae from wt mice treated with WAY-262611 shows statistically increased BFR, while similarly treated KO animals are no different from control. This indicates that WAY-262611 is acting via the Wnt
β
-catenin pathway and most likely through inhibition of Dkk-1.
MAY-262611
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-11035 | WAY-262611 | | 1 mg | 292元 |
| 2024/08/19 | HY-11035 | WAY-262611 | | 5 mg | 730元 |
1123231-07-1, MAY-262611 相关搜索:
- Inhibitors
- 药靶配体
- 抗体-一抗
- 试剂盒-Elisa试剂盒
- 抑制剂
- 细胞生物学试剂
- 小分子抑制剂，天然产物
- 小分子抑制剂
- 123231-07-1
- 2530-83-0
- ANTI-DKK1 ANTIBODY-抑癌蛋白DKK1抗体
- 抗体:MOUSE DKK1 ANTIBODY (MOR04454) RMB48101
- (1-(4-(萘-2-基)嘧啶-2-基)哌啶-4-基)甲胺
- WAY-262611游离态
- Β-联蛋白激动剂(WAY-262611)
- 1-[4-(2-萘基)-2-嘧啶基]-4-哌啶甲胺
- 1123231-07-1
- DKK1
- Dickkopf-1，DKK-1
- Human DKK1 Protein, His Tag
- Recombinant Human DKK-1/DKK1 Protein, 8* His Tag
- Recombinant Mouse Dkk-1 Protein, 8*His Tag
- WAY262611; WAY 262611
- CS-1296
- Wnt/β-catenin
- 1-{1-[4-(2-Naphthyl)-2-pyrimidinyl]-4-piperidinyl}methanamine
- 1-[4-(2-Naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine
- WAY-262611
- 4-PiperidineMethanaMine, 1-[4-(2-naphthalenyl)-2-pyriMidinyl]-
- MAY-262611
- 1-[4-(2-Naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine MAY-262611