MAY-262611
| 中文名称 | MAY-262611 |
|---|---|
| 中文同义词 | 1-[4-(2-萘基)-2-嘧啶基]-4-哌啶甲胺;Β-联蛋白激动剂(WAY-262611);WAY-262611游离态;(1-(4-(萘-2-基)嘧啶-2-基)哌啶-4-基)甲胺;抗体:MOUSE DKK1 ANTIBODY (MOR04454) RMB48101;ANTI-DKK1 ANTIBODY-抑癌蛋白DKK1抗体 |
| 英文名称 | MAY-262611 |
| 英文同义词 | 1-[4-(2-Naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine MAY-262611;MAY-262611;4-PiperidineMethanaMine, 1-[4-(2-naphthalenyl)-2-pyriMidinyl]-;WAY-262611;1-[4-(2-Naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine;1-{1-[4-(2-Naphthyl)-2-pyrimidinyl]-4-piperidinyl}methanamine;Wnt/β-catenin;CS-1296 |
| CAS号 | 1123231-07-1 |
| 分子式 | C20H22N4 |
| 分子量 | 318.42 |
| EINECS号 | 604-604-1 |
| 相关类别 | 小分子抑制剂;小分子抑制剂，天然产物;细胞生物学试剂;抑制剂;试剂盒-Elisa试剂盒;Inhibitors |
| Mol文件 | 1123231-07-1.mol |
| 结构式 |  |
MAY-262611 性质
| 沸点 | 544.8±42.0 °C(Predicted) |
|---|---|
| 密度 | 1.169±0.06 g/cm3(Predicted) |
| 储存条件 | under inert gas (nitrogen or Argon) at 2–8 °C |
| 溶解度 | DMF：30mg/mL； DMSO：30mg/mL；乙醇：50mg/mL；乙醇:PBS (pH 7.2) (1:1): 0.5 mg/mL |
| 形态 | 粉末 |
| 酸度系数(pKa) | 10.13±0.29(Predicted) |
| 颜色 | 浅黄至黄色 |
WAY-262611是 Wnt/β- 联蛋白激动剂，可增加骨形成速率，在 TCF- 荧光素酶测定实验中的 EC50 值为0.63 μM。WAY-262611 也是 Dkk1 的抑制剂。
EC50: 0.63 μM (β-Catenin)
WAY-262611 has the most potent activity in the primary assay, low kinase inhibition potential, and high solubility.
WAY-262611 has excellent pharmacokinetic properties and shows a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration. Calvariae from wt mice treated with WAY-262611 shows statistically increased BFR, while similarly treated KO animals are no different from control. This indicates that WAY-262611 is acting via the Wnt β -catenin pathway and most likely through inhibition of Dkk-1.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-11035 | WAY-262611 | 5 mg | 730元 | |
| 2024/04/30 | HY-11035 | MAY-262611 WAY-262611 | 1123231-07-1 | 10mM * 1mLin DMSO | 803元 |