7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇
中文名称 | 7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇 |
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中文同义词 | 化合物WAY 200070;7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇;WAY 200070,ERΒ激动剂 |
英文名称 | 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol |
英文同义词 | 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol;WAY 200070;7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol;WAY200070;WAY 200070;5-Benzoxazolol, 7-bromo-2-(4-hydroxyphenyl)-;7-Bromo-2-(4-hydroxyphenyl)benzo[d]oxazol-5-ol;Estrogen Receptor/ERR,WAY200070,WAY-200070,Inhibitor,inhibit |
CAS号 | 440122-66-7 |
分子式 | C13H8BrNO3 |
分子量 | 306.11 |
EINECS号 | 604-604-1 |
相关类别 | |
Mol文件 | 440122-66-7.mol |
结构式 |
7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇 性质
沸点 | 463.6±35.0 °C(Predicted) |
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密度 | 1.720±0.06 g/cm3(Predicted) |
储存条件 | Store at RT |
溶解度 | 二甲基亚砜:≥20mg/mL |
形态 | 固体 |
酸度系数(pKa) | 7.26±0.40(Predicted) |
颜色 | 白色至米白色 |
IC50: 2.3 nM (ERRβ), 155 nM (ERRα)
Administration of WAY-200070 (30 mg/kg s.c.) causes nuclear translocation of ERRβ receptors in WT mice. Administration of WAY-200070 (30 mg/kg s.c.) produces a delayed 50% increase in dopamine in the striatum of wild type mice. WAY-200070 (30 mg/kg s.c.) reduces immobility time in the mouse tail suspension test indicating an antidepressant-like effect. In gonadally intact male and female mice WAY-200070 increases agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected. Ovariectomized (ovx) mice treated with PPT fail to learn the socially acquired preference, while WAY-200070-treated ovx mice shows a two-fold prolonged preference for the food eaten by their demonstrator. WAY-200070, shows significantly decreased anxiety-like behaviors in both the open-field and elevated plus maze and significantly less depressive-like behaviors in the forced swim test.
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-101271 | WAY-200070 | 1 mg | 400元 | |
2024/04/30 | HY-101271 | 7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇 WAY-200070 | 440122-66-7 | 5mg | 880元 |