5-(苯磺酰基)-N-(哌啶-4-基)-2-(三氟甲基)苯磺酰胺
中文名称 | 5-(苯磺酰基)-N-(哌啶-4-基)-2-(三氟甲基)苯磺酰胺 |
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中文同义词 | 5-(苯磺酰基)-N-(哌啶-4-基)-2-(三氟甲基)苯磺酰胺;SFRP-1抑制剂(WAY 316606);化合物WAY 316606;方式 316606 |
英文名称 | BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- |
英文同义词 | BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)-;WAY 316606;WAY-316606;5-(Phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide;WAY-316606;WAY 316606;WAY316606;5-(benzenesulfonyl)-N-piperidin-4-yl-2-(trifluoromethyl)benzenesulfonamide;CS-2786;way-316606 /way 316606 |
CAS号 | 915759-45-4 |
分子式 | C18H19F3N2O4S2 |
分子量 | 448.48 |
EINECS号 | 1592732-453-0 |
相关类别 | 细胞生物学试剂;原料 |
Mol文件 | 915759-45-4.mol |
结构式 | ![]() |
5-(苯磺酰基)-N-(哌啶-4-基)-2-(三氟甲基)苯磺酰胺 性质
沸点 | 601.1±65.0 °C(Predicted) |
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密度 | 1.50±0.1 g/cm3(Predicted) |
溶解度 | DMF:3mg/mL; DMSO:3mg/mL; DMSO:PBS (pH 7.2) (1:10):0.1 mg/mL |
酸度系数(pKa) | 8.76±0.20(Predicted) |
形态 | 粉末 |
颜色 | 白色至米白色 |
Target | Value |
sFRP1
() |
The EC 50 of WAY-316606 for Wnt-Luciferase Activity from U2-OS Cells is 0.65 μM. WAY-316606 binds to secreted frizzled-related protein (sFRP)-1 inhibitor with a K D of 0.08 μM and inhibits sFRP-1 with an EC 50 of 0.65 μM. WAY-316606 also binds to sFRP-2, albeit over 10 times weaker with a K D of 1 μM. Using a fluorescence polarization binding assay that employs a fluorescent probe compound and purified human sFRP-1 protein in a competitive-binding format, the IC 50 for WAY-316606 is 0.5 μM.
WAY-316606 increases bone formation when tested in a neonatal murine calvarial assay. WAY-316606 increases total bone area up to 60% in a dose-dependent manner with an EC 50 of about 1 nM. WAY-316606 has good aqueous solubility, moderate to low inhibition of cytochrome p450 isozymes (3A4, 2D6, 2C9) and good stability in rat and human liver microsomes (t 1/2 >60 min in each species). In female Sprague-Dawley rats, WAY-316606 exhibits high plasma clearance (77 mL/min/kg, greater than hepatic blood flow) following a single intravenous bolus dose (2 mg/kg), which results in a rapid decline of drug exposure in the plasma despite the route of administration.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | S5815 | 5-(苯磺酰基)-N-(哌啶-4-基)-2-(三氟甲基)苯磺酰胺 WAY-316606 | 915759-45-4 | 2mg | 1204.47元 |
2024/04/30 | S5815 | 5-(苯磺酰基)-N-(哌啶-4-基)-2-(三氟甲基)苯磺酰胺 WAY-316606 | 915759-45-4 | 5mg | 1859.91元 |