米福贝特
|
|
|
- CAS号:
- 76541-72-5
- 英文名:
- SR 202
- 英文别名:
- SR 202;MIFOBATE;Clenicor;claniclor;SR-202 >=98% (HPLC), crystalline;Dimethyl (α-dimethoxyphosphinyl-p-chlorobenzyl) phosphate;DIMETHYL (ALPHA-DIMETHOXYPHOSPHINYL-P-CHLOROBENZYL) PHOSPHATE;(4-Chlorophenyl)(dimethoxyphosphoryl)methyl dimethyl phosphate;[(4-Chlorophenyl)(dimethoxyphosphinyl)methyl]dimethyl=phosphate;Dimethyl (α-dimethoxyphosphinyl-p-chlorobenzyl) phosphate, Mifobate
- 中文名:
- 米福贝特
- 中文别名:
- 米福酯;米福贝特;SR 202,PPARΓ拮抗剂;(4-氯苯基)(二甲氧基磷酰基)甲基 二甲基磷酸酯
- CBNumber:
- CB4285085
- 分子式:
- C11H17ClO7P2
- 分子量:
- 358.65
- MOL File:
- 76541-72-5.mol
|
|
|
米福贝特化学性质
-
沸点:
-
436.6±45.0 °C(Predicted)
-
|
-
密度:
-
1.355±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Inert atmosphere,Store in freezer, under -20°C
-
|
-
溶解度:
-
DMSO: 5 mg/mL
-
|
-
形态:
-
crystalline
-
|
-
颜色:
-
white
-
|
-
水溶解性:
-
Soluble to 100 mM in water
-
|
米福贝特性质、用途与生产工艺
Mifobate (SR-202) 是一种有效且特异性的 PPARγ 拮抗剂，可选择性的抑制噻唑烷二酮 (TZD) 诱导的 PPARγ 转录活性 (IC50=140 μM)。Mifobate 不影响 PPARα，PPARβ 或 FXR 的基础或配体刺激的转录活性。Mifobate 具有抗肥胖和抗糖尿病作用。
Mifobate (100-400 μM; pretreated with 24 hours) significantly inhibits BRL 49653- and hormone-induced adipocyte differentiation of 3T3-L1 cells in a dose-dependent manner after 6 days.
Mifobate is able to both interact specifically with PPARγ and inhibit its agonist-dependent interaction with the coactivator steroid receptor coactivator-1 (SRC-1). Mifobate (SR-202) inhibits TZD-stimulated recruitment of the coactivator steroid receptor coactivator-1. Mifobate blocks adipocyte differentiation induced either by thiazolidinediones or by the combination of dexamethasone, insulin, and 3-isobutyl-1-methylxanthine (IBMX).
Mifobate (400 mg/kg; Feed for 20 days) increases insulin sensitivity in ob/ob mice
|
Animal Model:
|
Eight-week-old male ob/ob mice
|
|
Dosage:
|
400 mg/kg
|
|
Administration:
|
Feed (food admixture maintained for 20 days)
|
|
Result:
|
Prevented the time-dependent increase in glucose concentrations.
|
米福贝特
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100277 | 米福贝特
Mifobate | 76541-72-5 | 1mg | 1100元 |
| 2024/04/30 | HY-100277 | 米福贝特
Mifobate | 76541-72-5 | 10mM * 1mLin DMSO | 2367元 |
米福贝特
生产厂家
全球有 59家供应商
米福贝特国内生产厂家
76541-72-5, 米福贝特 相关搜索:
- Intracellular receptor
- 药靶配体
- C11H17ClO7P2
- 6541-72-5
- SR 202,PPARΓ拮抗剂
- (4-氯苯基)(二甲氧基磷酰基)甲基 二甲基磷酸酯
- 米福贝特
- 米福酯
- 76541-72-5
- SR 202,diabetes,Peroxisome proliferator-activated receptors,adipocyte,stimulation,antiobesity,transcriptional,type 2,obesity,differentiation,PPAR,activity,selective,Mifobate,antidiabetic,inhibit,Inhibitor,SR202
- SR-202 >=98% (HPLC), crystalline
- (4-Chlorophenyl)(dimethoxyphosphoryl)methyl dimethyl phosphate
- Dimethyl (α-dimethoxyphosphinyl-p-chlorobenzyl) phosphate, Mifobate
- Dimethyl (α-dimethoxyphosphinyl-p-chlorobenzyl) phosphate
- Clenicor
- [(4-Chlorophenyl)(dimethoxyphosphinyl)methyl]dimethyl=phosphate
- phosphoricacid,(4-chlorophenyl)(dimethoxyphosphinyl)methyldimethylester
- claniclor
- MIFOBATE
- SR 202
- (4-CHLOROPHENYL)(DIMETHOXYPHOSPHINYL)METHYL PHOSPHORIC ACID DIMETHYL ESTER
- DIMETHYL (ALPHA-DIMETHOXYPHOSPHINYL-P-CHLOROBENZYL) PHOSPHATE