米福贝特
| 中文名称 | 米福贝特 |
|---|---|
| 中文同义词 | 米福酯;米福贝特;(4-氯苯基)(二甲氧基磷酰基)甲基 二甲基磷酸酯;SR 202,PPARΓ拮抗剂 |
| 英文名称 | SR 202 |
| 英文同义词 | DIMETHYL (ALPHA-DIMETHOXYPHOSPHINYL-P-CHLOROBENZYL) PHOSPHATE;(4-CHLOROPHENYL)(DIMETHOXYPHOSPHINYL)METHYL PHOSPHORIC ACID DIMETHYL ESTER;SR 202;MIFOBATE;claniclor;phosphoricacid,(4-chlorophenyl)(dimethoxyphosphinyl)methyldimethylester;[(4-Chlorophenyl)(dimethoxyphosphinyl)methyl]dimethyl=phosphate;Clenicor |
| CAS号 | 76541-72-5 |
| 分子式 | C11H17ClO7P2 |
| 分子量 | 358.65 |
| EINECS号 | |
| 相关类别 | Intracellular receptor |
| Mol文件 | 76541-72-5.mol |
| 结构式 |  |
米福贝特 性质
| 沸点 | 436.6±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.355±0.06 g/cm3(Predicted) |
| 储存条件 | Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | 在DMSO中的溶解度为5 毫克/毫升 |
| 形态 | 结晶 |
| 颜色 | 白色 |
| 水溶解性 | Soluble to 100 mM in water |
|
PPARγ 140 μM (IC 50 ) |
Mifobate (100-400 μM; pretreated with 24 hours) significantly inhibits BRL 49653- and hormone-induced adipocyte differentiation of 3T3-L1 cells in a dose-dependent manner after 6 days.
Mifobate is able to both interact specifically with PPARγ and inhibit its agonist-dependent interaction with the coactivator steroid receptor coactivator-1 (SRC-1). Mifobate (SR-202) inhibits TZD-stimulated recruitment of the coactivator steroid receptor coactivator-1. Mifobate blocks adipocyte differentiation induced either by thiazolidinediones or by the combination of dexamethasone, insulin, and 3-isobutyl-1-methylxanthine (IBMX).
Mifobate (400 mg/kg; Feed for 20 days) increases insulin sensitivity in ob/ob mice
| Animal Model: | Eight-week-old male ob/ob mice |
| Dosage: | 400 mg/kg |
| Administration: | Feed (food admixture maintained for 20 days) |
| Result: | Prevented the time-dependent increase in glucose concentrations. |
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 2 |
| RTECS号 | TB8817000 |
| 提供商 | 语言 |
|---|---|
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-100277 | 米福贝特 Mifobate | 76541-72-5 | 1mg | 880元 |
| 2024/08/19 | HY-100277 | 米福贝特 Mifobate | 76541-72-5 | 5mg | 2500元 |