去铁铵
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- CAS号:
- 138-14-7
- 英文名:
- DEFEROXAMINE MESYLATE
- 英文别名:
- DFOM;desferal;DESFERRIOXAMINE MESYLATE;deferoxaminebmesylate;Desferioxamine mesylate;desferrioxamine mesilate;DEFEROXAMINE MESYLATE SALT;Prestwick_988;desferalmesylate;deferoxaminemesilate
- 中文名:
- 去铁铵
- 中文别名:
- 去铁铵;甲磺酸除铁灵;甲磺酸去铁敏;甲磺酸去铁胺;去铁铵/去铁敏;去铁胺甲磺酸盐;去铁胺甲磺酸酯;去铁铵 USP标准品;甲磺酸去铁胺/去铁胺;甲磺酸去铁胺(湿水)
- CBNumber:
- CB4372020
- 分子式:
- C26H52N6O11S
- 分子量:
- 656.79
- MOL File:
- 138-14-7.mol
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去铁铵化学性质
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熔点:
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148-149°
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储存条件:
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2-8°C
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溶解度:
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H2O: 50 mg/mL
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形态:
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powder
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颜色:
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white to off-white
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水溶解性:
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Soluble to 100 mM in water
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去铁铵性质、用途与生产工艺
Deferoxamine mesylate (Desferrioxamine B, DFOM)是Deferoxamine的甲磺酸盐,它可形成铁络合物并用作螯合剂。Deferoxamine 是一种铁死亡的抑制剂,可在体外低氧和高血糖状态下稳定 HIF-1α 的表达并改善HIF-1α的活性。Deferoxamine 可降低 beta-amyloid (Aβ) 的沉积并诱导自噬。
Target | Value |
HIF-1α
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Beta Amyloid
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Ferroptosis
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Deferoxamine treatment significantly increases HIF-1α binding under all culture conditions, including hypoxic and high-glucose. The mechanism of deferoxamine is through improving HIF-1α biological function through scavenging oxygen free radicals. Deferoxamine (5 μM) has significant effect on the tumor-associated stromal cells cellular multiplication, and cells die at day 7 after exposure to 50 μM and 100 μM deferoxamine. Deferoxamine (5 μM-100 μM) inhibits the proliferation of BMMSCs, and induces apoptosis of MSCs in a dose-dependent manner. Deferoxamine influences the expression of adhesion proteins on MSCs. Deferoxamine (30, 60, 120 μM) shows lower expression of HIF-1α in a concentration dependent way in AdMSCs.
Deferoxamine (100 mg/kg, i.p.) lowers the mortality rate of subarachnoid hemorrhage (SAH) rat. Deferoxamine (100 mg/kg, i.p.) attenuates Evan’s blue extravasation in cortex, ameliorates the tight junction detachment and preserves the integrity of the base membrane examined in electron microscope at day 3 after SAH. Deferoxamine attenuates degradation of BBB proteins after SAH and significantly reduces ferritin expression at day 3 in the cortex, and improves neurologic behavior and cognitive deficits after experimental. Ten µL of 1 mM deferoxamine-treated wounds display significantly accelerated healing from day 7 onward and heal significantly faster than control-treated wounds in diabetic mice. Deferoxamine-treated wounds and dimethyloxalylglycine-treated wounds heal significantly faster than control-treated wounds in aged mice. In deferoxamine (10 mg/mL)-treated TG mice, there is a decrease in both soluble and insoluble Aβ40 and Aβ42. Both pGSK3β and β-catenin are significantly increased by approximately 50% in the deferoxamine-treated mice.
去铁铵
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | 46177 | 甲磺酸去铁胺 Deferoxamine mesylate, 95% | 138-14-7 | 1g | 3817元 |
2024/08/19 | S5742 | 去铁铵 Deferoxamine mesylate | 138-14-7 | 25mg | 1041.12元 |
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138-14-7, 去铁铵 相关搜索:
- Intermediates & Fine Chemicals
- Chelating Agents & Ligands
- Amines
- Aliphatics
- Pharmaceuticals
- DESFERAL
- Inhibitors
- 药靶配体
- 其他类
- 标准品
- 试剂盒-细胞分析试剂盒
- 医药原料
- 医药原料药-科研原料
- 小分子抑制剂,天然产物
- 小分子抑制剂
- 医药中间体
- C25H48N6O8CH4SO3
- C25H48N6O8CH4O3S
- C26H52N6O11S
- N1-(5-(4-((5-氨基戊基)氨基)-4-氧代丁酰胺)戊基)-N1-羟基-N4-(5-(N-羟基乙酰胺)戊基)丁二酰胺 甲磺酸盐
- 甲磺酸去铁胺(湿水)
- 去铁胺甲磺酸盐 EP标准品
- 去铁铵 USP标准品
- 甲磺酸去铁胺/去铁胺
- 去铁胺甲磺酸盐
- 去铁胺甲磺酸酯
- 去铁铵
- DEFEROX胺甲磺酸盐
- 去铁铵/去铁敏
- 甲磺酸除铁灵
- 甲磺酸去铁敏
- 甲磺酸去铁胺
- 138-14-7
- Deferoxamine mesylate USP/Ph. Eur
- Deferiprone Impurity 3
- HIFs,neovascularization,TAMSCs,diabetes mellitus,Akt,PKB,Protein kinase B,Apoptosis,Autophagy,SH-SY5Y,Hypoxia-inducible factors,Deferoxamine,Deferoxamine Mesylate,Inhibitor,MEFs,cancer,Alzheimer’s disease,HIF-PH,Reactive Oxygen Species,BMMSCs,inhibit,HIF/HIF Prolyl-Hydroxylase,COVID-19
- N1-(5-(4-((5-Aminopentyl)amino)-4-oxobutanamido)pentyl)-N1-hydroxy-N4-(5-(N-hydroxyacetamido)pentyl)succinamide methanesulfonate
- esferrioxamineBmesylate
- desferrioxamine mesilate
- Desferioxamine mesylate
- DEFEROXAMINE MESYLATE SALT
- DESFERRIOXAMINE MESYLATE
- DFOM
- desferal
- deferoxaminebmesylate
- Deferoxamine Mesylate (1166003)
- DEFEROXAMINE MESYLATE USP/EP/BP
- Deferoxamine for system suitability
- Deferoxamine mesilate CRS
- Deferoxamine Mesilate RS
- N4-[5-[[4-[[5-(Acetylhydroxyamino)pentyl]amino-1,4-dioxobutyl]hydroxyamino]pentyl]-N1-(5-aminopentyl)-N1-hydroxybutanediamide methanesulfonate
- DEFEROXAMINE MESYLATE
- DEFEROXAMINE METHANESULFONATE SALT
- Deferoxamine Mesylate (500 mg)
- Deferoxamine mesylate salt,DFOM, Deferoxamine methanesulfonate salt, Desferrioxamine mesylate salt
- Prestwick_988
- Desferrioxamine mesylate salt
- STARCHDEFEROXAMINECONJUGATE