DEFEROXAMINE MESYLATE
- CAS No.
- 138-14-7
- Chemical Name:
- DEFEROXAMINE MESYLATE
- Synonyms
- DFOM;desferal;DESFERRIOXAMINE MESYLATE;deferoxaminebmesylate;Desferioxamine mesylate;desferrioxamine mesilate;DEFEROXAMINE MESYLATE SALT;Prestwick_988;desferalmesylate;deferoxaminemesilate
- CBNumber:
- CB4372020
- Molecular Formula:
- C26H52N6O11S
- Molecular Weight:
- 656.79
- MDL Number:
- MFCD00058605
- MOL File:
- 138-14-7.mol
- MSDS File:
- SDS
| Melting point | 148-149° |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL |
| form | powder |
| color | white to off-white |
| Water Solubility | Soluble to 100 mM in water |
| FDA UNII | V9TKO7EO6K |
| NCI Drug Dictionary | deferoxamine mesylate |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| Safety Statements | 22-24/25 |
| WGK Germany | 2 |
| RTECS | UG5310000 |
| HS Code | 29280000 |
| Toxicity | man,TDLo,parenteral,16gm/kg/34W-I (16000mg/kg),CARDIAC: PERICARDITISGASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINEBLOOD: OTHER CHANGES,American Journal of Kidney Diseases. Vol. 10, Pg. 71, 1987. |
DEFEROXAMINE MESYLATE price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D9533 | Deferoxamine mesylate salt powder, ≥92.5% (TLC) | 138-14-7 | 1g | $142 | 2024-03-01 | Buy |
| Sigma-Aldrich | 252750 | Deferoxamine Mesylate - CAS 138-14-7 - Calbiochem Parenteralironchelatingagent.Commonlyusedintherapyasachelatorofferri | 138-14-7 | 1g | $210 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1166003 | Deferoxamine mesylate United States Pharmacopeia (USP) Reference Standard | 138-14-7 | 300mg | $436 | 2024-03-01 | Buy |
| Sigma-Aldrich | Y0001934 | Deferoxamine for system suitability European Pharmacopoeia (EP) Reference Standard | 138-14-7 | Y0001934 | $218 | 2023-06-20 | Buy |
| Cayman Chemical | 14595 | Deferoxamine (mesylate) ≥95% | 138-14-7 | 500mg | $73 | 2024-03-01 | Buy |
DEFEROXAMINE MESYLATE Chemical Properties,Uses,Production
Description
Deferoxamine is a bacterial siderophore that chelates iron. It is used to experimentally inhibit iron-
Chemical Properties
DEFEROXAMINE MESYLATE is white or almost white powder.
Uses
DEFEROXAMINE MESYLATE is an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients
Uses
chelating agent (Fe & Al)
brand name
Desferal (Novartis).
Biochem/physiol Actions
An iron chelator used often in the studies of cell proliferation and apoptosis. Has been shown to have anti-proliferative effects on vascular smooth muscle cells in vitro and in vivo and to arrest cells in the G1 phase. Also reported to induce p53. Induces apoptosis in HL-60 cells by chelating iron. After 48 hrs treatment with 1μM deferoxamine, DNA fragmentation was apparent. Cells treated with 0.1 μM deferoxamine for as little as 24 hours were committed to apoptosis; by 48 hrs nuclear collapse was observed. In some studies it has been shown to have antioxidant properties and to protect cells against H2O2-induced damage.
Clinical Use
Chelating agent:
Acute iron poisoning
Chronic iron or aluminium overload
Veterinary Drugs and Treatments
Deferoxamine is used for the treatment of either acute or chronic iron toxicity. It is being evaluated as an iron chelator for adjunctive treatment of acute cardiac ischemia and as a chelator for aluminum toxicity. Its efficacy in treating reperfusion injuries has been disappointing.
Drug interactions
Potentially hazardous interactions with other drugs
Avoid prochlorperazine, levomepromazine and
methotrimeprazine (prolonged unconsciousness).
Do not administer with blood.
Metabolism
When given parenterally desferrioxamine forms chelates with iron and aluminium ions to form ferrioxamine and aluminoxamine, respectively. The chelates are excreted in the urine and faeces via the bile. Desferrioxamine is metabolised, mainly in the plasma. Four metabolites of desferrioxamine were isolated from urine of patients with iron overload. The following biotransformation reactions were found to occur with desferrioxamine: transamination and oxidation yielding an acid metabolite, beta-oxidation also yielding an acid metabolite, decarboxylation and N-hydroxylation yielding neutral metabolites.
storage
Store at -20°C
DEFEROXAMINE MESYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20283 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 11817 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7724 | 58 |
View Lastest Price from DEFEROXAMINE MESYLATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-24 | DEFEROXAMINE MESYLATE
138-14-7
|
US $8.00-2.00 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2022-02-19 | DeferoxaMine Mesylate
138-14-7
|
US $0.00 / KG | 1KG | 98.4% | 100 tons | Honest Joy Holdings Limited
|
|
 |
2019-07-06 | DEFEROXAMINE MESYLATE
138-14-7
|
US $1.00 / KG | 1KG | 98% | 1kg,5kg,100kg | Career Henan Chemical Co |
-
- DEFEROXAMINE MESYLATE
138-14-7
- US $8.00-2.00 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- DeferoxaMine Mesylate
138-14-7
- US $0.00 / KG
- 98.4%
- Honest Joy Holdings Limited
-
- DEFEROXAMINE MESYLATE
138-14-7
- US $1.00 / KG
- 98%
- Career Henan Chemical Co