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DEFEROXAMINE MESYLATE

DEFEROXAMINE MESYLATE structure

CAS No.: 138-14-7

Chemical Name:: DEFEROXAMINE MESYLATE

Synonyms: DFOM;desferal;DESFERRIOXAMINE MESYLATE;deferoxaminebmesylate;Desferioxamine mesylate;desferrioxamine mesilate;DEFEROXAMINE MESYLATE SALT;Prestwick_988;desferalmesylate;deferoxaminemesilate

CBNumber:: CB4372020

Molecular Formula:: C26H52N6O11S

Molecular Weight:: 656.79

MDL Number:: MFCD00058605

MOL File:: 138-14-7.mol

MSDS File:: SDS

Last updated:2024-04-24 17:21:45

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DEFEROXAMINE MESYLATE Properties

Melting point	148-149°
storage temp.	2-8°C
solubility	H₂O: 50 mg/mL
form	powder
color	white to off-white
Water Solubility	Soluble to 100 mM in water
FDA UNII	V9TKO7EO6K
NCI Drug Dictionary	deferoxamine mesylate

Pharmacokinetic data

Protein binding	<10%
Excreted unchanged in urine	22%
Volume of distribution	2-2.5(L/kg)
Biological half-life	6 / -

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Safety Statements	22-24/25
WGK Germany	2
RTECS	UG5310000
HS Code	29280000
Toxicity	man,TDLo,parenteral,16gm/kg/34W-I (16000mg/kg),CARDIAC: PERICARDITISGASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINEBLOOD: OTHER CHANGES,American Journal of Kidney Diseases. Vol. 10, Pg. 71, 1987.

DEFEROXAMINE MESYLATE price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	D9533	Deferoxamine mesylate salt powder, ≥92.5% (TLC)	138-14-7	1g	$142	2024-03-01	Buy
Sigma-Aldrich	252750	Deferoxamine Mesylate - CAS 138-14-7 - Calbiochem Parenteralironchelatingagent.Commonlyusedintherapyasachelatorofferri	138-14-7	1g	$210	2024-03-01	Buy
Sigma-Aldrich	1166003	Deferoxamine mesylate United States Pharmacopeia (USP) Reference Standard	138-14-7	300mg	$436	2024-03-01	Buy
Sigma-Aldrich	Y0001934	Deferoxamine for system suitability European Pharmacopoeia (EP) Reference Standard	138-14-7	Y0001934	$218	2023-06-20	Buy
Cayman Chemical	14595	Deferoxamine (mesylate) ≥95%	138-14-7	500mg	$73	2024-03-01	Buy

Product number	Packaging	Price	Buy
D9533	1g	$142	Buy
252750	1g	$210	Buy
1166003	300mg	$436	Buy
Y0001934	Y0001934	$218	Buy
14595	500mg	$73	Buy

DEFEROXAMINE MESYLATE Chemical Properties,Uses,Production

Description

Deferoxamine is a bacterial siderophore that chelates iron. It is used to experimentally inhibit iron-dependent prolyl hydroxylases (EC₅₀ = 17.8 μM), thus preventing the degradation of isoforms of hypoxia inducible factor during normoxia. Deferoxamine has applications in diseases that are characterized by high levels of circulating iron, such as thalassemia major.

Chemical Properties

DEFEROXAMINE MESYLATE is white or almost white powder.

Uses

DEFEROXAMINE MESYLATE is an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients

Uses

chelating agent (Fe & Al)

brand name

Desferal (Novartis).

Biochem/physiol Actions

An iron chelator used often in the studies of cell proliferation and apoptosis. Has been shown to have anti-proliferative effects on vascular smooth muscle cells in vitro and in vivo and to arrest cells in the G1 phase. Also reported to induce p53. Induces apoptosis in HL-60 cells by chelating iron. After 48 hrs treatment with 1μM deferoxamine, DNA fragmentation was apparent. Cells treated with 0.1 μM deferoxamine for as little as 24 hours were committed to apoptosis; by 48 hrs nuclear collapse was observed. In some studies it has been shown to have antioxidant properties and to protect cells against H2O2-induced damage.

Clinical Use

Chelating agent:
Acute iron poisoning
Chronic iron or aluminium overload

Veterinary Drugs and Treatments

Deferoxamine is used for the treatment of either acute or chronic iron toxicity. It is being evaluated as an iron chelator for adjunctive treatment of acute cardiac ischemia and as a chelator for aluminum toxicity. Its efficacy in treating reperfusion injuries has been disappointing.

Drug interactions

Potentially hazardous interactions with other drugs
Avoid prochlorperazine, levomepromazine and methotrimeprazine (prolonged unconsciousness).
Do not administer with blood.

Metabolism

When given parenterally desferrioxamine forms chelates with iron and aluminium ions to form ferrioxamine and aluminoxamine, respectively. The chelates are excreted in the urine and faeces via the bile. Desferrioxamine is metabolised, mainly in the plasma. Four metabolites of desferrioxamine were isolated from urine of patients with iron overload. The following biotransformation reactions were found to occur with desferrioxamine: transamination and oxidation yielding an acid metabolite, beta-oxidation also yielding an acid metabolite, decarboxylation and N-hydroxylation yielding neutral metabolites.

storage

Store at -20°C

DEFEROXAMINE MESYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

DEFEROXAMINE MESYLATE Suppliers

Global( 200)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20287	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29882	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34553	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	7724	58
Dorne Chemical Technology co. LTD	+86-86-13583358881 +8618560316533	Ethan@dornechem.com	China	3096	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Shaanxi Dideu Medichem Co. Ltd	58
Dorne Chemical Technology co. LTD	58

View Lastest Price from DEFEROXAMINE MESYLATE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-24	DEFEROXAMINE MESYLATE 138-14-7	US $8.00-2.00 / kg	1kg	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2022-02-19	DeferoxaMine Mesylate 138-14-7	US $0.00 / KG	1KG	98.4%	100 tons	Honest Joy Holdings Limited
2019-07-06	DEFEROXAMINE MESYLATE 138-14-7	US $1.00 / KG	1KG	98%	1kg,5kg,100kg	Career Henan Chemical Co

DEFEROXAMINE MESYLATE
138-14-7
US $8.00-2.00 / kg
99%
Henan Fengda Chemical Co., Ltd

DeferoxaMine Mesylate
138-14-7
US $0.00 / KG
98.4%
Honest Joy Holdings Limited

DEFEROXAMINE MESYLATE
138-14-7
US $1.00 / KG
98%
Career Henan Chemical Co

DEFEROXAMINE MESYLATE Spectrum

DEFEROXAMINE MESYLATE(138-14-7)MS DEFEROXAMINE MESYLATE(138-14-7)¹HNMR

138-14-7(DEFEROXAMINE MESYLATE)Related Search:

Hydroxyurea Deferoxamine AMMONIUM FERRIC CHLORIDE Ammonium ferric sulfate dodecahydrate Ferric ammonium EDTA

Ferrous ammonium sulfate hexahydrate AMMONIUM IRON (III) HEXACYANOFERRATE (II) Ferric ammonium citrate,brown Ammonium iron(III) sulfate Ferric ammonium oxalate

MAFA Ammonium ferric citrate Ferric ammonium oxalate trihydrate DEFEROXAMINE MESYLATE NOCARDAMINE

ferrimycin A1 MAFA aqueous solution (5%) Deferoxamine Mesylate Salt

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deferoxaminemesilate deferoxaminemethanesulfonate desferalmesylate desferalmethanesulfonate desferrioxaminebmesylate Deferoxamine Mesylate (300 mg) N-[5-[3-[(5-aMinopentyl)hydroxycarbaMoyl]propionaMido]pentyl]-3-[[5-(N-hydroxyacetaMido) N1-(5-aMinopentyl)-N1-hydroxy-N4-[5-[[4-[[5-(acetylhydroxyaMino)pentyl]aMino]-1,4-dioxobutyl]hydroxyaMino]pentyl]butanediaMide Methanesulfonate desferrioxaminebmethanesulfonate monomethanesulfonate(sa propionohydroxamicacid,n-(5-(3-((5-aminopentyl)hydroxycarbamoyl)propionamido) Butanediamide, N-5-4-5-(acetylhydroxyamino)pentylamino-1,4-dioxobutylhydroxyaminopentyl-N-(5-aminopentyl)-N-hydroxy-, monomethanesulfonate (salt) STARCHDEFEROXAMINECONJUGATE Desferrioxamine mesylate salt Prestwick_988 Deferoxamine mesylate salt,DFOM, Deferoxamine methanesulfonate salt, Desferrioxamine mesylate salt Deferoxamine Mesylate (500 mg) DEFEROXAMINE METHANESULFONATE SALT DEFEROXAMINE MESYLATE N4-[5-[[4-[[5-(Acetylhydroxyamino)pentyl]amino-1,4-dioxobutyl]hydroxyamino]pentyl]-N1-(5-aminopentyl)-N1-hydroxybutanediamide methanesulfonate Deferoxamine Mesilate RS Deferoxamine mesilate CRS Deferoxamine for system suitability DEFEROXAMINE MESYLATE USP/EP/BP Deferoxamine Mesylate (1166003) deferoxaminebmesylate desferal DFOM DESFERRIOXAMINE MESYLATE DEFEROXAMINE MESYLATE SALT Desferioxamine mesylate desferrioxamine mesilate esferrioxamineBmesylate N1-(5-(4-((5-Aminopentyl)amino)-4-oxobutanamido)pentyl)-N1-hydroxy-N4-(5-(N-hydroxyacetamido)pentyl)succinamide methanesulfonate HIFs,neovascularization,TAMSCs,diabetes mellitus,Akt,PKB,Protein kinase B,Apoptosis,Autophagy,SH-SY5Y,Hypoxia-inducible factors,Deferoxamine,Deferoxamine Mesylate,Inhibitor,MEFs,cancer,Alzheimer’s disease,HIF-PH,Reactive Oxygen Species,BMMSCs,inhibit,HIF/HIF Prolyl-Hydroxylase,COVID-19 Deferoxamine mesylate USP/Ph. Eur Deferiprone Impurity 3 138-14-7 C26H52N6O11S C25H48N6O8CH4O3S C25H48N6O8CH4SO3 Inhibitors DESFERAL Pharmaceuticals Aliphatics Amines Chelating Agents & Ligands Intermediates & Fine Chemicals