亚叶酸
|
|
- CAS号:
- 58-05-9
- 英文名:
- Folinic acid
- 英文别名:
- LEUCOVORIN;levoleucovorin;5-formyltetrahydrofolic acid;N5-Formyl-H4F;5-formyltetrahydrofolate;Leucal;10-Formyl-7,8-dihydrofolic acid;CS-1326;Corticel;leucoverin
- 中文名:
- 亚叶酸
- 中文别名:
- 亚叶酸;菊白葉酸;5-甲酰四氢叶酸;5-甲酰-5,6,7,8-四氢叶酸;5-甲醯-5,6,7,8-四氫葉酸
- CBNumber:
- CB5681752
- 分子式:
- C20H23N7O7
- 分子量:
- 473.44
- MOL File:
- 58-05-9.mol
|
|
|
亚叶酸化学性质
-
熔点:
-
245°C (rough estimate)
-
|
-
沸点:
-
573.92°C (rough estimate)
-
|
-
比旋光度:
-
D20 +14.26° (c = 3.42 as anhydr Ca salt)
-
|
-
密度:
-
1.4485 (rough estimate)
-
|
-
折射率:
-
1.6800 (estimate)
-
|
-
储存条件:
-
under inert gas (nitrogen or Argon) at 2–8 °C
-
|
-
溶解度:
-
DMSO:172.5(Max Conc. mg/mL);364.35(Max Conc. mM)
-
|
-
酸度系数(pKa):
-
3.1, 4.8, 10.4(at 25℃)
-
|
-
形态:
-
Solid
-
|
-
颜色:
-
Pale Yellow to Light Yellow
-
|
-
水溶解性:
-
>1350g/L(25 ºC)
-
|
-
稳定性:
-
Hygroscopic
-
|
-
CAS 数据库:
-
58-05-9(CAS DataBase Reference)
-
|
亚叶酸性质、用途与生产工艺
亚叶酸(Leucovorin),化学名N-[4-[(2-氨基-5-甲酰基-1,4,5,6,7,8-六氢-4-氧代-6-蝶啶基)甲基]氨基]苯甲酰-L-谷氨酸,目前已被广泛应用于癌症的联合化疗。
亚叶酸通过叶酸盐的摄取吸收途径进入人体。一旦进入细胞它便迅速代谢为5-亚甲基四氢叶酸酯。5-亚甲基四氢叶酸酯是叶酸的活性形式,可以参与尿嘧啶转换为胸腺嘧啶的单碳转移反应。亚叶酸因此能够对抗叶酸拮抗剂引起的四氢叶酸酯形成受阻。
亚叶酸(亚叶酸钙)是还原型叶酸(folate)的一种特殊形式,给予CFD的儿童高剂量亚叶酸干预,可以改善他们的神经和发育异常。叶酸代谢异常与儿童自闭症发生有关。叶酸相关通路的基因多态性可能导致叶酸代谢异常。研究发现产前和受孕期间补充叶酸能够降低子代自闭症的发病风险。
左旋亚叶酸作为抗肿瘤的解毒剂和抗巨幼细胞贫血的辅助用药,其剂量是亚叶酸的1/2,左旋亚叶酸不需要被二氢叶酸还原酶还原即可参加利用叶酸盐作为一碳单位来源的反应,且左旋亚叶酸可以主动或被动地通过细胞膜;左旋亚叶酸基本作用和叶酸相同,但效果优于叶酸,同时左旋亚叶酸也具有刺激白细胞生长成熟的作用,能改善巨幼细胞性贫血。
Folinic acid (Leucovorin) 是一种生物叶酸,通常与甲氨蝶呤 (MTX) 一起作为挽救剂服用,以降低 MTX 诱导的毒性。
Human Endogenous Metabolite
|
MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) .
Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice).
Animal Model:
|
24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)
|
Dosage:
|
7.0 mg/kg
|
Administration:
|
Intraperitoneal injection; every second day; for 3 weeks
|
Result:
|
Following methotrexate (MTX) administration appears to reverse this growth inhibition.
|
亚叶酸
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/04/30 | XW585901 | 试剂Folinic acid Folinic acid | | 25mg | 135元 |
2024/04/30 | HY-17556 | 亚叶酸 Folinic acid | 58-05-9 | 5mg | 600元 |
亚叶酸
生产厂家
全球有 131家供应商
亚叶酸国内生产厂家
58-05-9, 亚叶酸 相关搜索:
- Pharmaceutical Raw Materials
- 合成有机化合物配体
- 医用原料
- 化学试剂
- 植物提取
- 原料药
- 医药中间体
- C21H24N6O7
- 58-09-6
- 5-甲酰四氢叶酸
- 5-甲酰-5,6,7,8-四氢叶酸
- 亚叶酸
- 菊白葉酸
- 5-甲醯-5,6,7,8-四氫葉酸
- 58-05-9
- LEUCOVORIN
- levoleucovorin
- Leucal
- 10-Formyl-7,8-dihydrofolic acid
- N5-Formyl-H4F
- 5-formyltetrahydrofolic acid
- 5-formyltetrahydrofolate
- CS-1326
- Folinic acid, leucovorin
- L-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
- Folic Acid Impurity 37(Folinic Acid)
- 5-formyltetrahydrofolicaci
- Folinic acid USP/EP/BP
- Leucovorin (Folinic acid)
- Folinic acid calcium hydrate salt
- Leucovorin D4
- 6-Methylprednisolone succinate sodium
- Asmacortone
- Corticel
- Metypresol
- (2S)-2-[[4-[(2-Amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
- LEUKOVORIN
- FOLINIC ACID
- N-[4-[[[[(6R)-2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxopteridin]-6-yl]methyl]amino]benzoyl]-L-glutamic acid
- (R)-Leucovorin
- (6R)-Leucovorin
- (6R)-5-Formyltetrahydrofolic acid
- (+)-N-[4-[[[(6R)-2-Amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxopteridin-6-yl]methyl]amino]benzoyl]-L-glutamic acid
- N-[4-[[[2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxopteridin-6-yl]methyl]amino]benzoyl]-L-glutamic acid
- N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxopteridin-6-yl)methyl]amino]benzoyl]-L-glutamic acid
- Welcovorin
- N5-Formyltetrahydrofolic acid
- N5-Formyl-5,6,7,8-tetrahydrofolic acid
- l-Leucovorin
- L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]- (9CI)
- Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, L- (8CI)
- 5-Formyltetrahydropteroylglutamic acid
- 5-Formyl-5,6,7,8-tetrahydrofolic acid
- (6R,S)-5-Formyltetrahydrofolate
- 2-[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid
- N5-formyl-tetrahydrofolate
- N5-formyl-5,6,7,8-tetrahydrofolate
- 5-formyl-5,6,7,8-tetrahydrofolate