RILMENIDINE HEMIFUMARATE SALT
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- CAS号:
- 207572-68-7
- 英文名:
- RILMENIDINE HEMIFUMARATE SALT
- 英文别名:
- LZFATBMLSYHRTC-WXXKFALUSA-N;RILMENIDINE HEMIFUMARATE SALT;n-(dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine hemifumarate salt;Oxaminozoline hemifumarate salt, Rilmenidene hemifumarate salt, N-(Dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine hemifumarate salt
- 中文名:
- RILMENIDINE HEMIFUMARATE SALT
- 中文别名:
- 利美尼定半富马酸盐;化合物 T21911
- CBNumber:
- CB5972920
- 分子式:
- 2C10H16N2O.C4H4O4
- 分子量:
- 476.57
- MOL File:
- 207572-68-7.mol
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RILMENIDINE HEMIFUMARATE SALT化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: >10mg/mL
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形态:
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solid
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颜色:
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white
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RILMENIDINE HEMIFUMARATE SALT性质、用途与生产工艺
Rilmenidine hemifumarate 是一种新型的抗高血压药物和口服活性选择性 I1 咪唑啉受体 (I1 imidazoline receptor) 激动剂。Rilmenidine hemifumarate 也是一种 α2 肾上腺素受体激动剂。Rilmenidine phosphate 诱导自噬 (autophagy)。Rilmenidine hemifumarate 可通过减少交感神经过度活跃而发挥中枢作用，并通过抑制 Na+/H+ 反向转运而在肾脏中发挥作用。Rilmenidine hemifumarate可调节白血病细胞增殖，刺激促凋亡蛋白 Bax，从而诱导人白血病 K562 细胞线粒体通路的紊乱和凋亡。
Rilmenidine provides antihypertensive efficacy comparable with that of diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors.
Rilmenidine (25-100 μM; 24 hours) inhibits K562 cell proliferation.
Cell Viability Assay
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Cell Line:
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K562 cells
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Concentration:
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25, 50, 100 μM
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Incubation Time:
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24 hours
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Result:
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Dose-dependently inhibited K562 colony formation.
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Rilmenidine-treated N171-82Q mice (i.p.; 4-times a week) displays significant improved forelimb grip strength and all limbs grip strength from 12 to 22 weeks of age.
Rilmenidine decreases levels of mutant huntingtin.
RILMENIDINE HEMIFUMARATE SALT
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下游产品
RILMENIDINE HEMIFUMARATE SALT
生产厂家
207572-68-7, RILMENIDINE HEMIFUMARATE SALT 相关搜索:
- 药靶配体
- C10H16N2O12C4H4O4
- C24H36N4O6
- 利美尼定半富马酸盐
- 化合物 T21911
- 207572-68-7
- LZFATBMLSYHRTC-WXXKFALUSA-N
- Oxaminozoline hemifumarate salt, Rilmenidene hemifumarate salt, N-(Dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine hemifumarate salt
- n-(dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine hemifumarate salt
- RILMENIDINE HEMIFUMARATE SALT