RILMENIDINE HEMIFUMARATE SALT
| 中文名称 | RILMENIDINE HEMIFUMARATE SALT |
|---|---|
| 中文同义词 | 化合物 T21911;利美尼定半富马酸盐;利美尼啶半富马酸盐 |
| 英文名称 | RILMENIDINE HEMIFUMARATE SALT |
| 英文同义词 | RILMENIDINE HEMIFUMARATE SALT;n-(dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine hemifumarate salt;Oxaminozoline hemifumarate salt, Rilmenidene hemifumarate salt, N-(Dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine hemifumarate salt;LZFATBMLSYHRTC-WXXKFALUSA-N |
| CAS号 | 207572-68-7 |
| 分子式 | 2C10H16N2O.C4H4O4 |
| 分子量 | 476.57 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 207572-68-7.mol |
| 结构式 |  |
RILMENIDINE HEMIFUMARATE SALT 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 二甲基亚砜：>10mg/mL |
| 形态 | 固体 |
| 颜色 | 白色 |
Rilmenidine hemifumarate 是一种新型的抗高血压药物和口服活性选择性 I1 咪唑啉受体 (I1 imidazoline receptor) 激动剂。Rilmenidine hemifumarate 也是一种 α2 肾上腺素受体激动剂。Rilmenidine phosphate 诱导自噬 (autophagy)。Rilmenidine hemifumarate 可通过减少交感神经过度活跃而发挥中枢作用，并通过抑制 Na+/H+ 反向转运而在肾脏中发挥作用。Rilmenidine hemifumarate可调节白血病细胞增殖，刺激促凋亡蛋白 Bax，从而诱导人白血病 K562 细胞线粒体通路的紊乱和凋亡。
Rilmenidine provides antihypertensive efficacy comparable with that of diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors.
Rilmenidine (25-100 μM; 24 hours) inhibits K562 cell proliferation.
Cell Viability Assay
| Cell Line: | K562 cells |
| Concentration: | 25, 50, 100 μM |
| Incubation Time: | 24 hours |
| Result: | Dose-dependently inhibited K562 colony formation. |
Rilmenidine-treated N171-82Q mice (i.p.; 4-times a week) displays significant improved forelimb grip strength and all limbs grip strength from 12 to 22 weeks of age.
Rilmenidine decreases levels of mutant huntingtin.
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| RTECS号 | RP7207400 |