利美尼啶
中文名称 | 利美尼啶 |
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中文同义词 | N-(双环丙基甲基)-4,5-二氢-2-噁唑胺;N-(二环丙烷基甲基)-4,5-二氢-2-噁唑胺;N-(双环丙基甲基)-4,5-二氢-2-唑胺;利美尼啶;瑞曼尼定;利美尼啶, 试剂级;N-(二环丙基甲基)-4,5-二氢噁唑-2-氨基;化合物 RILMENIDINE |
英文名称 | Rilmenidine |
英文同义词 | n-(dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine;oxaminozoline;RILMENIDINE;1,1-dicyclopropyl-n-(2-oxazolinyl)-methylamin;2-((dicyclopropylmethyl)imino)-oxazolidin;2-((dicyclopropylmethyl)imino)oxazolidine;2-(dicyclopropylmethylamino)-2-oxazoline;4,5-dihydro-n-(dicyclopropylmethyl)-2-oxazolamin |
CAS号 | 54187-04-1 |
分子式 | C10H16N2O |
分子量 | 180.25 |
EINECS号 | 259-021-0 |
相关类别 | 分子生物学;抗高血压药;心脑血管药物;药物;医药中间体;生化试剂;Antihypertensive;Imidazoline binding site;医药原料药;医药原料 |
Mol文件 | 54187-04-1.mol |
结构式 |
利美尼啶 性质
熔点 | 106-107° |
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沸点 | 355.5±9.0 °C(Predicted) |
密度 | 1.45±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | H2O: 7.3 mg/mL |
形态 | 固体 |
酸度系数(pKa) | 7.88±0.50(Predicted) |
颜色 | 白色 |
CAS 数据库 | 54187-04-1(CAS DataBase Reference) |
Rilmenidine provides antihypertensive efficacy comparable with that of diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors.
Rilmenidine (25-100 μM; 24 hours) inhibits K562 cell proliferation.
Cell Viability Assay
Cell Line: | K562 cells |
Concentration: | 25, 50, 100 μM |
Incubation Time: | 24 hours |
Result: | Dose-dependently inhibited K562 colony formation. |
Rilmenidine-treated N171-82Q mice (i.p.; 4-times a week) displays significant improved forelimb grip strength and all limbs grip strength from 12 to 22 weeks of age.
Rilmenidine decreases levels of mutant huntingtin.
磷酸利美尼定(Rilmenidine Phosphate):C10H16N2O?H3PO4。pKa 9.3。水中溶解度:约19%W/V;甲醇中溶解度:约7%W/V;氯仿和乙醇中溶解度:0.7%W/V。急性毒性LD50小鼠,大鼠(mg/kg):375,295口服。
方法2:化合物(I)和氯乙基异氰酸酯作用,直接得到的化合物(Ⅳ)。再环合得利美尼定。
安全信息
安全说明 | 22-24/25 |
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WGK Germany | 3 |
RTECS号 | RP7207400 |
提供商 | 语言 |
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英文
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