奥替那班
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- CAS号:
- 686344-29-6
- 英文名:
- Otenabant
- 英文别名:
- CS-1072;otenabant;Otenabant, >=98%;CP945598 free base;Otenabant (CP-945,598);CP 945598;OTENABANT;CP945598;CP 945598; CP-945598; CP945598;Otenabant (CP-945598 free base);1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxamide;4-Piperidinecarboxamide, 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)-
- 中文名:
- 奥替那班
- 中文别名:
- 奥替那班;1-[9-(4-氯苯基)-8-(2-氯苯基)-9H-嘌呤-6-基]-4-乙基氨基哌啶-4-甲酰胺;1-(8-(2-氯苯基)-9-(4-氯苯基)-9H-嘌呤-6-基)-4-(乙氨基)哌啶-4-甲酰胺
- CBNumber:
- CB61518526
- 分子式:
- C25H25Cl2N7O
- 分子量:
- 510.42
- MOL File:
- 686344-29-6.mol
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奥替那班化学性质
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沸点:
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757.9±70.0 °C(Predicted)
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密度:
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1.46
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 100 mg/mL (195.92 mM; Need ultrasonic)
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形态:
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Powder
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酸度系数(pKa):
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16.30±0.20(Predicted)
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颜色:
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White to off-white
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奥替那班性质、用途与生产工艺
Otenabant 是一种有效的，选择性的 cannabinoid receptor CB1 拮抗剂，Ki 值为 0.7 nM，对其选择性是对 CB2 的 1000 多倍。
Otenabant HCl has low affinity with K
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of 7.6 μM for human CB2 receptors. Otenabant HCl inhibits CB1 receptor with moderate unbound microsomal clearance, low hERG affinity, and adequate CNS penetration.
Otenabant acutely stimulates energy expenditure in rats and decreases the respiratory quotient indicating a metabolic switch to increased fat oxidation. Otenabant (10 mg/kg, p.o.) promotes a 9%, vehicle adjusted weight loss in a 10 day weight loss study in diet-induced obese mice. Otenabant HCl reverses four cannabinoid agonistmediated behaviors (locomotor activity, hypothermia, analgesia, and catalepsy) following administration of the synthetic CB1 receptor agonist CP-55940. Otenabant HCl exhibits dose-dependent anorectic activity in a model of acute food intake in rodents and increased energy expenditure and fat oxidation.
奥替那班
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-10871 | 奥替那班
Otenabant | 686344-29-6 | 5mg | 500元 |
| 2024/08/19 | HY-10871 | 奥替那班
Otenabant | 686344-29-6 | 10mM * 1mLin DMSO | 561元 |
686344-29-6, 奥替那班 相关搜索:
- 合成有机化合物配体
- 医药
- G蛋白偶联受体&G蛋白
- C25H25Cl2N7O
- 1-(8-(2-氯苯基)-9-(4-氯苯基)-9H-嘌呤-6-基)-4-(乙氨基)哌啶-4-甲酰胺
- 奥替那班
- 1-[9-(4-氯苯基)-8-(2-氯苯基)-9H-嘌呤-6-基]-4-乙基氨基哌啶-4-甲酰胺
- 686344-29-6
- Otenabant (CP-945598 free base)
- CS-1072
- CP 945598; CP-945598; CP945598
- CP 945598;OTENABANT;CP945598
- 4-Piperidinecarboxamide, 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)-
- CP945598 free base
- Otenabant, >=98%
- Otenabant (CP-945,598)
- 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxamide
- otenabant