奥替那班
| 中文名称 | 奥替那班 |
|---|---|
| 中文同义词 | 1-[9-(4-氯苯基)-8-(2-氯苯基)-9H-嘌呤-6-基]-4-乙基氨基哌啶-4-甲酰胺;奥替那班;1-(8-(2-氯苯基)-9-(4-氯苯基)-9H-嘌呤-6-基)-4-(乙氨基)哌啶-4-甲酰胺 |
| 英文名称 | Otenabant |
| 英文同义词 | otenabant;1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxamide;Otenabant (CP-945,598);Otenabant, >=98%;CP945598 free base;4-Piperidinecarboxamide, 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)-;CP 945598;OTENABANT;CP945598;CP 945598; CP-945598; CP945598 |
| CAS号 | 686344-29-6 |
| 分子式 | C25H25Cl2N7O |
| 分子量 | 510.42 |
| EINECS号 | |
| 相关类别 | G蛋白偶联受体&G蛋白;医药 |
| Mol文件 | 686344-29-6.mol |
| 结构式 |  |
奥替那班 性质
| 沸点 | 757.9±70.0 °C(Predicted) |
|---|---|
| 密度 | 1.46 |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：100 mg/mL（195.92 mM；需要超声波） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 16.30±0.20(Predicted) |
| 颜色 | 白色至米白色 |
Ki: 0.7 nM (CB1)
Otenabant HCl has low affinity with K i of 7.6 μM for human CB2 receptors. Otenabant HCl inhibits CB1 receptor with moderate unbound microsomal clearance, low hERG affinity, and adequate CNS penetration.
Otenabant acutely stimulates energy expenditure in rats and decreases the respiratory quotient indicating a metabolic switch to increased fat oxidation. Otenabant (10 mg/kg, p.o.) promotes a 9%, vehicle adjusted weight loss in a 10 day weight loss study in diet-induced obese mice. Otenabant HCl reverses four cannabinoid agonistmediated behaviors (locomotor activity, hypothermia, analgesia, and catalepsy) following administration of the synthetic CB1 receptor agonist CP-55940. Otenabant HCl exhibits dose-dependent anorectic activity in a model of acute food intake in rodents and increased energy expenditure and fat oxidation.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-10871 | 奥替那班 Otenabant | 686344-29-6 | 5mg | 500元 |
| 2024/04/30 | HY-10871 | 奥替那班 Otenabant | 686344-29-6 | 10mM * 1mLin DMSO | 561元 |