安乃近杂质C
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- CAS号:
- 856307-27-2
- 英文名:
- MetaMizole IMpurity C (4-MethylaMinoantipyrine) HCl
- 英文别名:
- Metamizole EP Impurity C;Metamizole EP Impurity C HCl;4-Methylamino-1,5-dimethyl-2-phenyl;4-Methylaminophenazone Hydrochloride;4-Methylaminoantipyrine hydrochloride;Metamizole EP Impurity C Hydrochloride;N-Methyl-4-aminoantipyrine Hydrochloride;Antipyrine,4-(methylamino)-, hydrochloride;4-Methylaminoantipyrine hydrochloride in methanol;MetaMizole IMpurity C (4-MethylaMinoantipyrine) HCl
- 中文名:
- 安乃近杂质C
- 中文别名:
- 安乃近杂质C;安乃近杂质C(EP);安乃近EP杂质C HCL;4-甲氨基安替比林盐酸盐;安乃近杂质C(EP) 标准品;N-甲基-4-氨基安替比林盐酸盐;4-METHYLAMINOANTIPYRINE HYDROCHLORIDE;化合物 4-METHYLAMINO ANTIPYRINE HYDROCHLORIDE
- CBNumber:
- CB62706986
- 分子式:
- C12H16ClN3O
- 分子量:
- 253.73
- MOL File:
- 856307-27-2.mol
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安乃近杂质C化学性质
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熔点:
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>195°C
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储存条件:
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Hygroscopic, -20°C Freezer, Under inert atmosphere
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溶解度:
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Chloroform (Slightly, Sonicated), DMSO (Slightly), Water (Slightly)
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形态:
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Solid
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颜色:
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Pale Orange to Light Brown
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稳定性:
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Hygroscopic
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安乃近杂质C性质、用途与生产工艺
4-Methylamino antipyrine hydrochloride 是一种 Metamizole 的活性代谢产物。Metamizole 是吡唑啉酮类非甾体抗炎药 (NSAID)，是一种有效的 COX 抑制剂。Metamizole 是一种非阿片类镇痛药，可用于疼痛和发烧。4-Methylamino antipyrine hydrochloride 具有止痛，解热和相对较弱的抗炎特性。
Metamizole is a prodrug which, at room temperature and in an atmosphere with oxygen, is spontaneously, nonenzymatically converted to 4-Methylamino antipyrine. Subsequently, the N-methyl side chain of 4-Methylamino antipyrine is oxidized to yield 4-formylaminoantipyrine, which is further converted to 4-aminoantipyrine. Metamizole in aqueous solution and in the presence of oxygen consists of a group of several pyrazolone derivatives of which 4-Methylamino antipyrine is pharmacologically the most important.
The aim of this study is to assess the pharmacokinetics of its active metabolites 4-Methylamino antipyrine in male piglets after a single intramuscular injection of Metamizole. Eight healthy male piglets are administered Metamizole (100 mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentrations are quantitatively detectable from 0.25 to 48 h. The average maximum concentration of 4-Methylamino antipyrine is of 47.59 mg/mL. The average half-lives is 8.57 h for 4-Methylamino antipyrine.
安乃近杂质C
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-135731A | 安乃近杂质C
4-Methylamino antipyrine hydrochloride | 856307-27-2 | 100mg | 2450元 |
| 2024/01/25 | HY-135731A | 安乃近杂质C
4-Methylamino antipyrine hydrochloride | 856307-27-2 | 25mg | 1050元 |
856307-27-2, 安乃近杂质C 相关搜索:
- 抑制剂
- 化合物 4-METHYLAMINO ANTIPYRINE HYDROCHLORIDE
- 安乃近EP杂质C HCL
- 4-METHYLAMINOANTIPYRINE HYDROCHLORIDE
- 安乃近杂质C(EP) 标准品
- N-甲基-4-氨基安替比林盐酸盐
- 安乃近杂质C(EP)
- 4-甲氨基安替比林盐酸盐
- 安乃近杂质C
- 856307-27-2
- 4-Methylaminoantipyrine hydrochloride in methanol
- Metamizole Sodium Monohydrate EP Impurity C as Hydrochloride
- Metamizole EP Impurity C Hydrochloride
- Metamizole EP Impurity C
- 1,5-dimethyl-4-(methylamino)-2-phenylpyrazol-3-one:hydrochloride
- 4-Methylaminophenazone Hydrochloride
- Antipyrine,4-(methylamino)-, hydrochloride
- Metamizole EP Impurity C HCl
- 4-Methylaminoantipyrine hydrochloride
- N-Methyl-4-aminoantipyrine Hydrochloride
- 4-Methylamino-1,5-dimethyl-2-phenyl
- 3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-, hydrochloride
- MetaMizole IMpurity C (4-MethylaMinoantipyrine) HCl