安乃近杂质C
中文名称 | 安乃近杂质C |
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中文同义词 | 安乃近杂质C;4-甲氨基安替比林盐酸盐;安乃近杂质C(EP);N-甲基-4-氨基安替比林盐酸盐;安乃近杂质C(EP) 标准品;4-METHYLAMINOANTIPYRINE HYDROCHLORIDE;安乃近EP杂质C HCL |
英文名称 | MetaMizole IMpurity C (4-MethylaMinoantipyrine) HCl |
英文同义词 | MetaMizole IMpurity C (4-MethylaMinoantipyrine) HCl;3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-, hydrochloride;4-Methylamino-1,5-dimethyl-2-phenyl;N-Methyl-4-aminoantipyrine Hydrochloride;4-Methylaminoantipyrine hydrochloride;Metamizole EP Impurity C HCl;Antipyrine,4-(methylamino)-, hydrochloride;4-Methylaminophenazone Hydrochloride |
CAS号 | 856307-27-2 |
分子式 | C12H16ClN3O |
分子量 | 253.73 |
EINECS号 | |
相关类别 | |
Mol文件 | 856307-27-2.mol |
结构式 | ![]() |
安乃近杂质C 性质
熔点 | >195°C |
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储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
溶解度 | 可溶于氯仿(轻微,超声处理)、DMSO(轻微)、水(轻微) |
形态 | 固体 |
颜色 | 浅橙色至浅棕色 |
稳定性 | 吸湿性 |
COX
Metamizole is a prodrug which, at room temperature and in an atmosphere with oxygen, is spontaneously, nonenzymatically converted to 4-Methylamino antipyrine. Subsequently, the N-methyl side chain of 4-Methylamino antipyrine is oxidized to yield 4-formylaminoantipyrine, which is further converted to 4-aminoantipyrine. Metamizole in aqueous solution and in the presence of oxygen consists of a group of several pyrazolone derivatives of which 4-Methylamino antipyrine is pharmacologically the most important.
The aim of this study is to assess the pharmacokinetics of its active metabolites 4-Methylamino antipyrine in male piglets after a single intramuscular injection of Metamizole. Eight healthy male piglets are administered Metamizole (100 mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentrations are quantitatively detectable from 0.25 to 48 h. The average maximum concentration of 4-Methylamino antipyrine is of 47.59 mg/mL. The average half-lives is 8.57 h for 4-Methylamino antipyrine.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-135731A | 安乃近杂质C 4-Methylamino antipyrine hydrochloride | 856307-27-2 | 100mg | 2450元 |
2024/01/25 | HY-135731A | 安乃近杂质C 4-Methylamino antipyrine hydrochloride | 856307-27-2 | 25mg | 1050元 |