疣孢菌素
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- CAS号:
- 3148-09-2
- 英文名:
- MUCONOMYCIN A
- 英文别名:
- vera;Verrucarin;NSC 126728;VERRUCARIN A;Verrucarine A;MUCONOMYCIN A;Muconomycin A, NSC 126728;16a,21-trimethyl--stereoisomer;verrucarin A from myrothecium sp;n-17(18h),2’-oxirane)-3,9,14-trione,4,5,6,7,16,16a,19a,22-octahydro-4-hydroxy
- 中文名:
- 疣孢菌素
- 中文别名:
- 疣孢菌素;疣孢菌素A;化合物 VERRUCARIN A
- CBNumber:
- CB6328001
- 分子式:
- C27H34O9
- 分子量:
- 502.55
- MOL File:
- 3148-09-2.mol
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疣孢菌素化学性质
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熔点:
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>360° (dec)
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比旋光度:
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D23 +206° (c = 1.012 in chloroform)
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沸点:
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512.66°C (rough estimate)
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密度:
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1.1922 (rough estimate)
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折射率:
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1.5500 (estimate)
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储存条件:
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−20°C
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溶解度:
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Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
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形态:
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A solid
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酸度系数(pKa):
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12.76±0.70(Predicted)
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颜色:
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White to light yellow
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疣孢菌素性质、用途与生产工艺
Verrucarin A (Muconomycin A) 是一种 D 型大环真菌毒素,来源于Myrothecium verrucaria,是一种蛋白质合成 (protein synthesis) 的抑制剂。Verrucarin A 抑制白血病细胞系生长,激活巨噬细胞 caspases、凋亡和炎症信号。Verrucarin A 能有效提高 p38 MAPK 的磷酸化,降低 ERK/Akt 的磷酸化。Verrucarin A 通过 p21 和 p53 的诱导引起细胞周期调控的解除。
Verrucarin A (0-0.6 μM/ml; 24-48 hours)-induces time- and dose-dependent growth inhibition in MCF-7 cells.
Verrucarin A increases the levels of reactive oxygen species (ROS), and subsequently induces mitochondrial membrane potential (Δψm) loss, leading to the increase of Bax/Bcl-2 ratio, cytochrome c release, caspase activation, PARP degradation, and apoptosis.
Cell Viability Assay
Cell Line:
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MCF-7 cells
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Concentration:
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0-0.6 μM/ml
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Incubation Time:
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24 and 48 hours
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Result:
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Growth of MCF-7 cells is significantly inhibited in a dose- and time-dependent manner, with the IC
50
s of 0.41 and 0.29 μM/ml for 24- and 48-h treatment periods, respectively.
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疣孢菌素
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-107426 | 疣孢菌素 Verrucarin A | 3148-09-2 | 1mg | 2000元 |
2024/08/19 | HY-107426 | 疣孢菌素 Verrucarin A | | 5 mg | 7300元 |
疣孢菌素
生产厂家
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疣孢菌素国内生产厂家
3148-09-2, 疣孢菌素 相关搜索:
- 抑制剂
- C27H34O9
- C26H32O9
- 314-89-2
- 化合物 VERRUCARIN A
- 疣孢菌素A
- 疣孢菌素
- 3148-09-2
- Verrucarine A
- n-17(18h),2’-oxirane)-3,9,14-trione,4,5,6,7,16,16a,19a,22-octahydro-4-hydroxy
- 16a,21-trimethyl--stereoisomer
- VERRUCARIN A
- MUCONOMYCIN A
- NSC 126728
- verrucarin A from myrothecium sp
- Muconomycin A, NSC 126728
- Verrucarin
- vera
- spiro(16,18-methano-1h,3h,23h-(1,6,12)trioxacyclooctadecino(3,4-d)(1)benzopyra