ASTX-029
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- CAS号:
- 2095719-92-7
- 英文名:
- ASTX-029
- 英文别名:
- ASTX-029;ERK1/2 inhibitor 2;ERK1/2 inhibitor 2(ASTX-029);ERK-1/2 inhibitor 2,Extracellular signal regulated kinases,Inhibitor,ASTX 029,ERK1/2 inhibitor 2,inhibit,ERK;(2R)-2-[6-[5-chloro-2-(tetrahydropyran-4-ylamino)pyrimidin-4-yl]-1-oxo-isoindolin-2-yl]-N-[(1S)-1-(3-fluoro-5-methoxy-phenyl)-2-hydroxy-ethyl]propanamide;(R)-2-(6-(5-chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1-oxoisoindolin-2-yl)-N-((S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl)propanamide;2H-Isoindole-2-acetamide, 6-[5-chloro-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-N-[(1S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl]-1,3-dihydro-α-methyl-1-oxo-, (αR)-
- 中文名:
- ASTX-029
- 中文别名:
- 化合物ASTX029;(R)-2-(6-(5-氯-2-((四氢-2H-吡喃-4-基)氨基)嘧啶-4-基)-1-氧代异吲哚啉-2-基)-N-((S)-1-(3-氟-5-甲氧基苯基)-2-羟乙基)丙酰胺
- CBNumber:
- CB64664325
- 分子式:
- C29H31ClFN5O5
- 分子量:
- 584.05
- MOL File:
- 2095719-92-7.mol
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ASTX-029化学性质
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密度:
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1.387±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 250 mg/mL (428.05 mM)
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形态:
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A crystalline solid
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酸度系数(pKa):
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13.39±0.46(Predicted)
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颜色:
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White to off-white
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InChIKey:
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BVRGQPJKSKKGIH-YZMAQOALNA-N
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SMILES:
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O=C1N(CC2=CC=C(C3C(=CN=C(NC4CCOCC4)N=3)Cl)C=C12)[C@H](C)C(=O)N[C@@H](C1C=C(F)C=C(OC)C=1)CO |&1:24,29,r|
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ASTX-029性质、用途与生产工艺
ASTX-029 是一种口服生物利用的 extracellular signal-regulated kinases (ERK) 1 and 2 的抑制剂，具有潜在的抗肿瘤活性。ASTX-029 可抑制ERK依赖性肿瘤细胞的增殖和存活。
| Target | Value |
ERK1
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ERK2
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ASTX-029
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-126288 | ASTX029 | | 1 mg | 545元 |
| 2024/11/08 | HY-126288 | ASTX-029
ASTX029 | 2095719-92-7 | 5 mg | 1200元 |
2095719-92-7, ASTX-029 相关搜索:
- 抑制剂
- C29H31ClFN5O5
- (R)-2-(6-(5-氯-2-((四氢-2H-吡喃-4-基)氨基)嘧啶-4-基)-1-氧代异吲哚啉-2-基)-N-((S)-1-(3-氟-5-甲氧基苯基)-2-羟乙基)丙酰胺
- 化合物ASTX029
- 2095719-92-7
- (2R)-2-[6-[5-chloro-2-(tetrahydropyran-4-ylamino)pyrimidin-4-yl]-1-oxo-isoindolin-2-yl]-N-[(1S)-1-(3-fluoro-5-methoxy-phenyl)-2-hydroxy-ethyl]propanamide
- ERK-1/2 inhibitor 2,Extracellular signal regulated kinases,Inhibitor,ASTX 029,ERK1/2 inhibitor 2,inhibit,ERK
- ERK1/2 inhibitor 2
- ERK1/2 inhibitor 2(ASTX-029)
- (R)-2-(6-(5-chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1-oxoisoindolin-2-yl)-N-((S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl)propanamide
- 2H-Isoindole-2-acetamide, 6-[5-chloro-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-N-[(1S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl]-1,3-dihydro-α-methyl-1-oxo-, (αR)-
- ASTX-029