SHA 68
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- CAS号:
- 847553-89-3
- 英文名:
- SHA 68
- 英文别名:
- SHA 68;N-(4-fluorobenzyl)-3-oxo-1,1-diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxamide;N-(4-Fluorobenzyl)-3-oxo-1,1-diphenyltetrahydro-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide;N-[(4-Fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide;N-[(4-fluorophenyl)methyl]-3-oxo-1,1-diphenyl-hexahydro-1H-[1,3]oxazolo[3,4-a]pyrazine-7-carboxamide;3H-Oxazolo[3,4-a]pyrazine-7(1H)-carboxamide, N-[(4-fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-
- 中文名:
- SHA 68
- 中文别名:
- 化合物SHA 68;SHA 68,神经肽S受体拮抗剂;N-(4-氟苄基)-3-氧代-1,1-二苯基四氢-3H-恶唑并[3,4-A]吡嗪-7(1H)-甲酰胺;N-(4-氟苄基)-3-氧代-1,1-二苯基四氢-1H-恶唑并[3,4-A]吡嗪-7(3H)-羧酰胺
- CBNumber:
- CB73037532
- 分子式:
- C26H24FN3O3
- 分子量:
- 445.49
- MOL File:
- 847553-89-3.mol
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SHA 68化学性质
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沸点:
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727.8±60.0 °C(Predicted)
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密度:
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1.35±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 16 mg/ml; DMSO: 14 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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13.32±0.40(Predicted)
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颜色:
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White to off-white
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SHA 68性质、用途与生产工艺
SHA 68 是一种有效的选择性非肽神经肽 S 受体 (NPSR) 拮抗剂,对 NPSR Asn107 和 NPSR Ile107 的 IC50 分别为 22.0 和 23.8 nM。SHA 68 具有有限的血脑屏障 (BBB) 渗透能力和用于神经痛的活性。
IC50: 22 nM (Asn
107
) and 23.8 nM (Ile
107
)
SHA 68 (i.p.; 5 and 50 mg/kg) reduces NPS-induced horizontal activity and vertical rearing and climbing.
SHA 68 (i.v.; 1 mg/kg) has a T
1/2
of 0.74 hours, a CL of 4.29 mL/min/kg, and a V
ss
of 2.53 L/kg.
SHA 68 (i.p.; 2.5 mg/kg) has a T
1/2
of 0.43 hours, a CL of 4.56 mL/min/kg.
Animal Model:
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Male C57BL/6 mice age 8-12 weeks
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Dosage:
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5 and 50 mg/kg
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Administration:
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i.p.
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Result:
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Reduced NPS-induced horizontal activity and vertical rearing and climbing.
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Animal Model:
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Male C57BL/6 mice age 8-12 weeks
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Dosage:
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1 mg/kg (Pharmacokinetic Analysis)
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Administration:
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i.p.
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Result:
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Had a T
1/2
of 0.74 hours, a CL of 4.29 mL/min/kg, and a V
ss
of 2.53 L/kg.
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SHA 68
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/08/19 | HY-108625 | SHA 68 | | 5 mg | 825元 |
2024/08/19 | HY-108625 | SHA 68 SHA 68 | 847553-89-3 | 10mM * 1mLin DMSO | 907元 |
847553-89-3, SHA 68 相关搜索:
- 合成有机化合物配体
- N-(4-氟苄基)-3-氧代-1,1-二苯基四氢-3H-恶唑并[3,4-A]吡嗪-7(1H)-甲酰胺
- SHA 68,神经肽S受体拮抗剂
- 化合物SHA 68
- N-(4-氟苄基)-3-氧代-1,1-二苯基四氢-1H-恶唑并[3,4-A]吡嗪-7(3H)-羧酰胺
- 847553-89-3
- N-[(4-fluorophenyl)methyl]-3-oxo-1,1-diphenyl-hexahydro-1H-[1,3]oxazolo[3,4-a]pyrazine-7-carboxamide
- N-(4-Fluorobenzyl)-3-oxo-1,1-diphenyltetrahydro-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide
- 3H-Oxazolo[3,4-a]pyrazine-7(1H)-carboxamide, N-[(4-fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-
- N-[(4-Fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide
- N-(4-fluorobenzyl)-3-oxo-1,1-diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxamide
- SHA 68