SHA 68
- CAS No.
- 847553-89-3
- Chemical Name:
- SHA 68
- Synonyms
- SHA 68;N-(4-fluorobenzyl)-3-oxo-1,1-diphenyltetrahydro-1H-oxazolo[3,4-a]pyrazine-7(3H)-carboxamide;N-(4-Fluorobenzyl)-3-oxo-1,1-diphenyltetrahydro-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide;N-[(4-Fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide;N-[(4-fluorophenyl)methyl]-3-oxo-1,1-diphenyl-hexahydro-1H-[1,3]oxazolo[3,4-a]pyrazine-7-carboxamide;3H-Oxazolo[3,4-a]pyrazine-7(1H)-carboxamide, N-[(4-fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-
- CBNumber:
- CB73037532
- Molecular Formula:
- C26H24FN3O3
- Molecular Weight:
- 445.49
- MDL Number:
- MFCD22683843
- MOL File:
- 847553-89-3.mol
- MSDS File:
- SDS
| Boiling point | 727.8±60.0 °C(Predicted) |
|---|---|
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 16 mg/ml; DMSO: 14 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/ml |
| form | A crystalline solid |
| pka | 13.32±0.40(Predicted) |
| color | White to off-white |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
SHA 68 price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1459 | SHA 68 ≥98% (HPLC) | 847553-89-3 | 5MG | $91.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1459 | SHA 68 ≥98% (HPLC) | 847553-89-3 | 25MG | $462 | 2024-03-01 | Buy |
| Cayman Chemical | 21512 | SHA-68 ≥95% | 847553-89-3 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 21512 | SHA-68 ≥95% | 847553-89-3 | 5mg | $88 | 2024-03-01 | Buy |
| Cayman Chemical | 21512 | SHA-68 ≥95% | 847553-89-3 | 10mg | $160 | 2024-03-01 | Buy |
SHA 68 Chemical Properties,Uses,Production
Description
SHA-68 is an antagonist of the neuropeptide S receptor (NPSR; IC50s = 22 and 23.8 nM for the NPSR Asn107 and NPSR Ile107 isoforms, respectively). It is selective for NPSR over a panel of 14 G protein-coupled receptors exhibiting no activity at a concentration of 10 μM. SHA-68 (50 mg/kg) reduces NPS-induced horizontal activity and vertical rearing and climbing in mice. SHA-68 also reduces conditioned reinstatement of cocaine seeking in rats.
Uses
SHA 68 is a selective neuropeptide S antagonist.
in vivo
SHA 68 (i.p.; 5 and 50 mg/kg) reduces NPS-induced horizontal activity and vertical rearing and climbing[1].
SHA 68 (i.v.; 1 mg/kg) has a T1/2 of 0.74 hours, a CL of 4.29 mL/min/kg, and a Vss of 2.53 L/kg[1].
SHA 68 (i.p.; 2.5 mg/kg) has a T1/2 of 0.43 hours, a CL of 4.56 mL/min/kg[1].
| Animal Model: | Male C57BL/6 mice age 8-12 weeks[1] |
| Dosage: | 5 and 50 mg/kg |
| Administration: | i.p. |
| Result: | Reduced NPS-induced horizontal activity and vertical rearing and climbing. |
| Animal Model: | Male C57BL/6 mice age 8-12 weeks[1] |
| Dosage: | 1 mg/kg (Pharmacokinetic Analysis) |
| Administration: | i.p. |
| Result: | Had a T1/2 of 0.74 hours, a CL of 4.29 mL/min/kg, and a Vss of 2.53 L/kg. |
storage
Store at +4°C
SHA 68 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32202 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |