红陪酚
|
|
- CAS号:
- 569-77-7
- 英文名:
- PURPUROGALLIN
- 英文别名:
- C09964;MLS0007;NSC 35676;NSC 646653;AIDS138915;CHEBI:8647;AIDS-138915;AKOS 209-004;KBio1_001351;KBio2_000828
- 中文名:
- 红陪酚
- 中文别名:
- 红陪酚;红倍酚;1,2,3,9-四羟基苯并[7]环庚烯-8-酮;1,2,3,9-四羟基-8-苯并[7]环庚烯酮;5H-苯并环庚烯-5-酮,2,3,4,6-四羟基-;2,3,4,6-四羟基-5H-苯并[A]环庚烯-5-酮;2,3,4,6-四羟基-5H-苯并[7]环庚烯-5-酮
- CBNumber:
- CB7329636
- 分子式:
- C11H8O5
- 分子量:
- 220.18
- MOL File:
- 569-77-7.mol
|
|
|
红陪酚化学性质
-
熔点:
-
275 °C (dec.)(lit.)
-
|
-
沸点:
-
321.11°C (rough estimate)
-
|
-
密度:
-
1.3824 (rough estimate)
-
|
-
折射率:
-
1.5140 (estimate)
-
|
-
储存条件:
-
−20°C
-
|
-
溶解度:
-
DMSO (Slightly), Methanol (Slightly)
-
|
-
形态:
-
Solid
-
|
-
酸度系数(pKa):
-
6.75±0.20(Predicted)
-
|
-
颜色:
-
Very Dark Brown
-
|
-
Merck:
-
7946
-
|
-
稳定性:
-
Air Sensitive
-
|
-
LogP:
-
2.050 (est)
-
|
红陪酚性质、用途与生产工艺
Purpurogallin 是从栎属植物中提取的天然酚,具有强的黄嘌呤氧化酶 (Xanthine Oxidase) 抑制活性,其 IC50 为 0.2 µM。Purpurogallin 具有抗氧化和抗炎作用。
IC50: 0.2 µM (xanthine oxidase)
Purpurogallin (50 or 100 µM; 7 or 25 hours; BV2 murine microglial cells) treatment attenuates the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression in LPS-stimulated BV2 microglial cells.
Purpurogallin (100 µM; 75-120 minutes; BV2 murine microglial cells) exhibits anti-inflammatory properties by suppressing the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways in LPS-stimulated BV2 microglial cells.
RT-PCR
Cell Line:
|
BV2 murine microglial cells
|
Concentration:
|
50 or 100 µM
|
Incubation Time:
|
7 or 25 hours
|
Result:
|
Attenuated the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression.
|
Western Blot Analysis
Cell Line:
|
BV2 murine microglial cells
|
Concentration:
|
100 µM
|
Incubation Time:
|
75 minutes, 90 minutes, 120 minutes
|
Result:
|
Suppressed the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways.
|
Purpurogallin (100-400 μg/kg; intraperitoneal injection; for 48 or 72 hours; male Sprague-Dawley rats) exerts its neuroinflammation effect through the dual effect of inhibiting IL-6 and TNF-α mRNA expression and reducing HMGB1 protein and mRNA expression.
Animal Model:
|
Fifty-four male Sprague-Dawley rats (250-350 g) with subarachnoid hemorrhage (SAH)
|
Dosage:
|
100 μg/kg, 200 μg/kg, 400 μg/kg
|
Administration:
|
Intraperitoneal injection; for 48 or 72 hours
|
Result:
|
Dose-dependently reduced HMGB1 protein expression. High dose reduced TNF-α and HMGB1 mRNA levels.
|
红陪酚
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/08/19 | HY-12136 | Purpurogallin | | 1 mg | 228元 |
2024/08/19 | HY-12136 | 红陪酚 Purpurogallin | 569-77-7 | 5mg | 500元 |
红陪酚
生产厂家
全球有 53家供应商
红陪酚国内生产厂家
569-77-7, 红陪酚 相关搜索:
4-烯丙基邻苯二酚 3,4-二羟基苯甲醛 4-乙基间苯二酚 2,3,4-三羟基苯甲醛 2,3-二羟基苯甲醛 4-烯丙基苯酚 红陪酚 2,3-二羟基苯乙酮 3,4,5-三羥甲苯 2,3-二甲酚 邻苯三酚 2,3,4-三羟基苯乙酮 羟基酪醇 邻甲基苯乙醇 2'-羟基苯乙酮 2-羟基苯乙酮 对羟基苯乙烯 2,4-二羟基苯乙酮
- Tropolones & Azulenes
- Tropolones
- 有机化工原料
- 对照品
- Tropolones & Azulenes
- Tropolones
- 1,2,3,9-四羟基苯并[7]环庚烯-8-酮
- 1,2,3,9-四羟基-8-苯并[7]环庚烯酮
- 5H-苯并环庚烯-5-酮,2,3,4,6-四羟基-
- 2,3,4,6-四羟基-5H-苯并[A]环庚烯-5-酮
- 2,3,4,6-四羟基-5H-苯并[7]环庚烯-5-酮
- 红陪酚
- 红倍酚
- 569-77-7
- Inhibitor,inhibit,Purpurogallin,Xanthine Oxidase
- 2,3,4,5-tetrahydroxy-6-benzo[7]annulenone
- 5H-Benzocyclohepten-5-one, 2,3,4,6-tetrahydroxy-
- Spectrum4_001547
- SPECTRUM210505
- Spectrum2_000582
- Spectrum_000348
- SPBio_000424
- SDCCGMLS-0066536.P001
- Oprea1_685478
- NCGC00095229-02
- NCGC00095229-01
- MLS0007
- KBioSS_000828
- KBio3_001663
- KBio2_005964
- KBio2_003396
- KBio2_000828
- KBio1_001351
- DivK1c_006407
- CHEBI:8647
- C09964
- AIDS-138915
- AIDS138915
- PURPUROGALLIN, TECH.
- 2,3,4,6-Tetrahydroxy-5H-benzo[a]cyclohepten-5-one
- 2,3,4,6-tetrahydroxy-5H-benzo[7]annulen-5-one
- 1,2,3,9-tetrahydroxybenzo[7]annulen-8-one
- 1,2,3,9-tetrahydroxy-8-benzo[7]annulenone
- NSC 646653
- NSC 35676
- BENZOCYCLOHEPTENE-5-ONE,2,3,4,6-TETRAHYDROXY-
- PURPUROGALLINE
- PURPUROGALLIN(RG)
- PURPUROGALLIN
- AKOS 209-004
- 2,3,4,6-TETRAHYDROXY-BENZOCYCLOHEPTEN-5-ONE
- 2,3,4,6-tetrahydroxy-5h-benzocycloheptene-5-one
- 2,3,4,6-tetrahydroxy-5h-benzocycloheptene-5-on