抗黴素A1
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- CAS号:
- 642-15-9
- 英文名:
- ANTIMYCIN A1
- 英文别名:
- ANTIMYCIN A1;dihydrosamidin;1,5-Dioxonane butanoic acid deriv.;-dioxo-1,5-dioxonan-3-yl)salicylamide;isovalericacid,8-esterwith3-formamido-n-(7-hexyl-8-hydroxy-4,9-dimethyl-2,6;3-(3-formamidosalicylamido)-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl isovalerate;[3-[(3-formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate;[3-[(3-formamido-2-hydroxy-phenyl)carbonylamino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate;3-methylbutyric acid [3-[(3-formamido-2-hydroxy-benzoyl)amino]-8-hexyl-4,9-diketo-2,6-dimethyl-1,5-dioxonan-7-yl] ester;3-Methylbutyric acid 3-[[3-(formylamino)-2-hydroxybenzoyl]amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl ester
- 中文名:
- 抗黴素A1
- 中文别名:
- 抗霉素A1;二氢沙米丁;二氫沙米汀;抗黴素A1;抗黴素A1,二氢沙米丁
- CBNumber:
- CB9479432
- 分子式:
- C28H40N2O9
- 分子量:
- 548.63
- MOL File:
- 642-15-9.mol
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抗黴素A1化学性质
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熔点:
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149.5℃
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比旋光度:
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D26 +76° (c = 1 in chloroform)
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沸点:
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620.81°C (rough estimate)
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密度:
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1.2468 (rough estimate)
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折射率:
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1.5800 (estimate)
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储存条件:
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−20°C
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溶解度:
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DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
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形态:
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A solid
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抗黴素A1性质、用途与生产工艺
Antimycin A1 是泛醇-细胞色素 c 氧化还原酶的特定电子转移 (electron transfer) 抑制剂。Antimycin A1 通过抑制 HIF-1α 激活导致的 VEGF 产生减少来抑制血管生成。
Antimycin A, a mixture of Antimycins A1, A2, A3, and A4, is an antibiotic produced by
Streptomyces
species and displays antifungal, insecticidal, nematocidal, and piscicidal properties. Antimycin A inhibits Bcl-2 and Bcl-xL proteins, inducing apoptosis.
化学性质
白色结晶。不溶于水,溶于乙醇,易溶于丙酮和氯仿。Mp149-150℃ (A1),170-171.5℃(A3);A1在乙醇中最大吸收波长为226nm和320nm,A3在甲醇中最大吸收波长是225nm和320nm;A1的比旋光度[α]
26D+76°(1%,氯仿),A3为+64.3°(氯仿)。低毒,LD
50(大鼠,经口)1469mg/kg(A1)。
用途
琥珀酸氧化酶的抑制剂,生物色素系统电子传递阻断剂及细胞呼吸抑制剂,并具有抗病毒和抗真菌作用。
生产方法
链霉菌培养液经醇提、浓缩制得复合物粗晶,再在甲醇:水:四氯化碳:己烷中逆流分配分离而得纯品。
抗黴素A1
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2022/09/18 | HY-107406 | 抗黴素A1 Antimycin A1 | 642-15-9 | 500μg | 5600元 |
2022/09/18 | HY-107406 | 抗黴素A1 Antimycin A1 | 642-15-9 | 1mg | 9600元 |
抗黴素A1
生产厂家
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抗黴素A1国内生产厂家
642-15-9, 抗黴素A1 相关搜索:
- 抑制剂
- 实验室通用药物
- 生物化学品
- 生化试剂
- 微生物代谢物
- C28H40N2O9
- C16H21NO2
- 抗黴素A1,二氢沙米丁
- 抗霉素A1
- 二氢沙米丁
- 二氫沙米汀
- 抗黴素A1
- 642-15-9
- 1,5-Dioxonane butanoic acid deriv.
- 3-methylbutyric acid [3-[(3-formamido-2-hydroxy-benzoyl)amino]-8-hexyl-4,9-diketo-2,6-dimethyl-1,5-dioxonan-7-yl] ester
- [3-[(3-formamido-2-hydroxy-phenyl)carbonylamino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate
- [3-[(3-formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate
- 3-Methylbutyric acid 3-[[3-(formylamino)-2-hydroxybenzoyl]amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl ester
- 3-Methylbutanoic acid 3-[[3-(formylamino)-2-hydroxybenzoyl]amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl ester
- 3-(3-formamidosalicylamido)-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl isovalerate
- ANTIMYCIN A1
- isovalericacid,8-esterwith3-formamido-n-(7-hexyl-8-hydroxy-4,9-dimethyl-2,6
- -dioxo-1,5-dioxonan-3-yl)salicylamide
- dihydrosamidin