BATRACHOTOXIN

23509-16-2

CAS-Nr.: 23509-16-2

Englisch Name:: BATRACHOTOXIN

Synonyma:: BTX;C13750;BATRACHOTOXIN;ISNYUQWBWALXEY-OMIQOYQYSA-N;Batrachotoxinin A, 20-(2,4-dimethyl-1H-pyrrole-3-carboxylate);1H-Pyrrole-3-carboxylicacid, 2,4-dimethyl-,(1S)-1-[(5aR,7aR,9R,11aS,11bS,12R,13aR)-1,2,3,4,7a,8,9,10,11,11a,12,13-dodecahydro-9,12-dihydroxy-2,11a-dimethyl-7H-9,11b-epoxy-13a,5a-propenophenanthro[2,1-;(1S)-1-[(5aR,7aR,9R,11aS,11bS,12R,13aR)-1,2,3,4,7a,8,9,10,11,11a,12,13-Dodecahydro-9,12-dihydroxy-2-11a-dimethyl-7H-9,11b-epoxy-13a,5a-propenophenanthro[2,1-f][1,4]oxazepin-14-yl]ethyl2,4-dimethyl-1H-pyrrole-3-carboxylate;1H-Pyrrole-3-carboxylic acid, 2,4-dimethyl-, (1S)-1-[(5aR,7aR,9R,11aS,11bS,12R,13aR)-1,2,3,4,7a,8,9,10,11,11a,12,13-dodecahydro-9,12-dihydroxy-2,11a-dimethyl-7H-9,11b-epoxy-13a,5a-propenophenanthro[2,1-f][1,4]oxazepin-14-yl]ethyl ester

CBNumber:: CB01431991

Summenformel:: C31H42N2O6

Molgewicht:: 538.67

MOL-Datei:: 23509-16-2.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 9

BATRACHOTOXIN Eigenschaften

alpha: 24584 -5 To -10°; 24300 -260° (c = 0.23 in methanol)

Siedepunkt:: 614.87°C (rough estimate)

Dichte: 1.1575 (rough estimate)

Brechungsindex: 1.5800 (estimate)

storage temp.: Store at -20°C

pka: 7.45(at 25℃)

Aggregatzustand: Thin film.

Farbe: Noncrystal

CAS Datenbank: 23509-16-2

EPA chemische Informationen: Betrachotoxinin A, 20-.alpha.-(2,4-dimethyl-1H-pyrrole-3-carboxylate) (23509-16-2)

Sicherheit

RIDADR	3172
HazardClass	6.1(b)
PackingGroup	III
Giftige Stoffe Daten	23509-16-2(Hazardous Substances Data)
Toxizität	LD50 s.c. in mice: 2 mg/kg (Tokuyama)

BATRACHOTOXIN Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Noncrystal.

Hazard

Extremely toxic; deadly poison; neurotoxic; cardiotoxic activity; bara-chotoxin that blocks neuromuscular transmission; respiratory paralysis; death.

Biologische Aktivität

Potent neurotoxin that activates voltage-gated sodium channels. Shifts voltage-dependent activation to more negative potentials, inactivation is disabled and pore conductance and selectivity are altered (displays increased permeability for NH 4 + , K + and Cs + ions).

Sicherheitsprofil

A deadly poison byintraperitoneal, intravenous, and subcutaneous routes.When heated to decomposition it emits toxic fumes ofNOx.

Enzyminhibitor

This lipid-soluble neurotoxin (FW = 526.67 g/mol; CAS 23509-16-2; LD50 = ~2 μg/kg mouse body weight.), isolated from the skin of the Columbian poison-dart frog Phyllobates aurotaenis, enhances Na+ conductance, promoting opening of voltage-gated Na+ channels, inducing depolarization of the resting membrane potential. It does so by binding to the sodium channel, keeping the membrane permeable to sodium ions in an all-or-none manner. This results in hyperexcitability of excitable tissues, followed by convulsions, paralysis, and death in animals. The most common use of batrachotoxin is in darts for bloguns used in hunting by the Noanamá Chocó and Emberá Chocó Indians of western Colombia. Batrachotoxin has also been identified in the feathers of the passerine birds of New Guinea Pitohui dichrous, Pitohui kirhocephalus, and Ifrita kowaldi. The less toxic batrachotoxin A is the deesterified steroid.

BATRACHOTOXIN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

BATRACHOTOXIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 9)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Dorne Chemical Technology co. LTD	+86-86-13583358881 +8618560316533	Ethan@dornechem.com	China	3146	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49999	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58

23509-16-2()Verwandte Suche:

Tetracainhydrochlorid Aconitin 4,9-Epoxycevan-3β,4α,12,14,16β,17,20-heptol-3-veratrumat Tetrodotoxin [R-(E)]-5,6-Dihydro-4-methoxy-6-styryl-2H-pyran-2-on 1-Methyl-4-(1-methylvinyl)cyclohexan-1-ol (1α,2β,5α)-2-Methyl-5-(1-methylvinyl)cyclohexan-1-ol

Batrachotoxinin A, 20-(2,4-dimethyl-1H-pyrrole-3-carboxylate)
C13750
(1S)-1-[(5aR,7aR,9R,11aS,11bS,12R,13aR)-1,2,3,4,7a,8,9,10,11,11a,12,13-Dodecahydro-9,12-dihydroxy-2-11a-dimethyl-7H-9,11b-epoxy-13a,5a-propenophenanthro[2,1-f][1,4]oxazepin-14-yl]ethyl2,4-dimethyl-1H-pyrrole-3-carboxylate
BATRACHOTOXIN
1H-Pyrrole-3-carboxylic acid, 2,4-dimethyl-, (1S)-1-[(5aR,7aR,9R,11aS,11bS,12R,13aR)-1,2,3,4,7a,8,9,10,11,11a,12,13-dodecahydro-9,12-dihydroxy-2,11a-dimethyl-7H-9,11b-epoxy-13a,5a-propenophenanthro[2,1-f][1,4]oxazepin-14-yl]ethyl ester
ISNYUQWBWALXEY-OMIQOYQYSA-N
BTX
1H-Pyrrole-3-carboxylicacid, 2,4-dimethyl-,(1S)-1-[(5aR,7aR,9R,11aS,11bS,12R,13aR)-1,2,3,4,7a,8,9,10,11,11a,12,13-dodecahydro-9,12-dihydroxy-2,11a-dimethyl-7H-9,11b-epoxy-13a,5a-propenophenanthro[2,1-
23509-16-2
Sodium channel