MESORIDAZINE Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Mesoridazine acts analogous to other phenothiazine neuroleptics and is used for schizophrenia, behavioral problems, psychoneurotic displays, and in severe and chronic alcoholism.
Trademarks
Lidanar (Novartis).
Synthese
Mesoridazine, 10-[2-(1-methyl-2-piperidyl)ethyl]-2-(methylsufinyl)phenothiazine (6.1.13), is synthesized by an analogous scheme, however, it is also synthesized
by alkylating the acidic form of 2-methylthiphenothiazine—methylsulfonylphenothiazine —
using 2-(2-chlorethyl)-1-methylpiperidine.
In order to do this, 2-methylthiophenothiazine is initially acylated at the nitrogen atom
using acetic anhydride, giving 10-acetyl-2-methylthiophenothiazine (6.1.10). The resulting acetyl derivative is further oxidized by hydrogen peroxide into 10-acetyl-2-methylsulfonylpenothiazine (6.1.11). Deacylation of this product in potassium carbonate methanol
solution gives 2-methylsulfonylphenothiazine (6.1.12), which is alkylated by 2-(2-chlorethyl)-1-methylpiperidine in the presence of sodium amide, affording the desired mesoridazine (6.1.13) [31].
MESORIDAZINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
