MESORIDAZINE
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MESORIDAZINE 속성
- 녹는점
- 126 - 131°C (dec.)
- 저장 조건
- Hygroscopic, Refrigerator, under inert atmosphere
- 용해도
- 아세토니트릴(약간 용해됨), DMSO(약간 용해됨, 가열), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 연한 노란색에서 주황색까지
- 안정성
- 흡습성
안전
MESORIDAZINE C화학적 특성, 용도, 생산
용도
Mesoridazine acts analogous to other phenothiazine neuroleptics and is used for schizophrenia, behavioral problems, psychoneurotic displays, and in severe and chronic alcoholism.상표명
Lidanar (Novartis).Synthesis
Mesoridazine, 10-[2-(1-methyl-2-piperidyl)ethyl]-2-(methylsufinyl)phenothiazine (6.1.13), is synthesized by an analogous scheme, however, it is also synthesized by alkylating the acidic form of 2-methylthiphenothiazine—methylsulfonylphenothiazine — using 2-(2-chlorethyl)-1-methylpiperidine.In order to do this, 2-methylthiophenothiazine is initially acylated at the nitrogen atom using acetic anhydride, giving 10-acetyl-2-methylthiophenothiazine (6.1.10). The resulting acetyl derivative is further oxidized by hydrogen peroxide into 10-acetyl-2-methylsulfonylpenothiazine (6.1.11). Deacylation of this product in potassium carbonate methanol solution gives 2-methylsulfonylphenothiazine (6.1.12), which is alkylated by 2-(2-chlorethyl)-1-methylpiperidine in the presence of sodium amide, affording the desired mesoridazine (6.1.13) [31].
MESORIDAZINE 준비 용품 및 원자재
원자재
준비 용품
MESORIDAZINE 공급 업체
글로벌( 17)공급 업체
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