Colforsin

Forskolin Struktur
66575-29-9
CAS-Nr.
66575-29-9
Bezeichnung:
Colforsin
Englisch Name:
Forskolin
Synonyma:
HL 362;CS-736;Forsklin;COLEONOL;Boforsin;ForsLean;FORSKOLIN;COLFORSIN;NSC 35708;Forskolii
CBNumber:
CB0167677
Summenformel:
C22H34O7
Molgewicht:
410.5
MOL-Datei:
66575-29-9.mol

Colforsin Eigenschaften

Schmelzpunkt:
282-232 °C
Siedepunkt:
520℃
alpha 
D25 -26.19° (c = 1.68 in CHCl3)
Dichte
1.23
Brechungsindex
1.5300 (estimate)
Flammpunkt:
172℃
storage temp. 
room temp
Löslichkeit
DMSO: 5 mg/mL stable at least 6 months at room temperature
Aggregatzustand
powder
pka
11.00±0.70(Predicted)
Farbe
off-white
Wasserlöslichkeit
Soluble in ethanol, dimethylsulfoxide and chloroform. Insolule in water.
maximale Wellenlänge (λmax)
305nm(lit.)
Merck 
14,2476
BRN 
1692716
Stabilität:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
InChIKey
OHCQJHSOBUTRHG-KGGHGJDLSA-N
LogP
2.406 (est)
CAS Datenbank
66575-29-9
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 21
S-Sätze: 22-36/37
WGK Germany  3
RTECS-Nr. QL6150000
10-21
HS Code  29329990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H312 Gesundheitsschädlich bei Hautkontakt. Akute Toxizität dermal Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P280,P302+P352, P312, P322, P363,P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Colforsin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R21:Gesundheitsschädlich bei Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.

Chemische Eigenschaften

Colorless Crystalline Solid

Verwenden

Forskolin is a diterpene isolated from Coleus forskohlii, possessing vasodilating and cardiostimulatory properties. Forskolin resensitizes cell receptors by activating the enzyme adenylyl cyclase and increasing the intracellular levels of cAMP.

Allgemeine Beschreibung

Forskolin, present predominantly in the root of Coleus forskohlii plant, is a potential pharmacological compound. It is used for treating hypertension, respiratory disorders and obesity. Forskolin is a diterpenoid capable of modulating adenylate cyclase enzyme and cyclic adenosine monophosphate (cAMP) levels. Engineering forskolin biosynthetic pathway caters its commercial production for pharmacological use. Forskolin has antioxidant and anti-inflammatory property and reduces hyperglycemia by stimulating insulin release. Forskolin promotes differentiation of hepatoma HepaRG cells and activates farnesoid X receptor (FXR) and pregnane X receptor(PXR).

Biologische Aktivität

Cell-permeable activator of adenylyl cyclase. Hypotensive and vasodilatory agent. Induces neuronal differentiation in stem cells and in several neuroblastoma. Also available as part of the PKA Tocriset™ .

läuterung methode

It is an antihypertensive, a positive ionotropic, a platelet aggregation inhibitor, and it has adenylate cyclase activating properties [Chem Abstr 89 244150 1978, de Souza et al. Med Res Rev 3 201 1983, X-ray: Tandon et al. Indian J Chem 15B 880 1977]. [Beilstein 18/5 V 55.]

Colforsin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Colforsin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 438)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12837 58
Chongqing Zhihe Biopharmaceutical Co., Ltd.
+8618580541567
sales@zhswyy.com China 303 58
Hebei Saisier Technology Co., LTD
+86-18400010335 +86-18034520335
admin@hbsaisier.cn China 1015 58
BINBO BIOLOGICAL CO.,LTD
+8618629063126
info@binbobiological.com China 346 58
Hebei Longbang Technology Co., LTD
+86-18633929156 +86-18633929156
admin@hblongbang.com China 941 58
HebeiShuoshengImportandExportco.,Ltd
+86-18532138899 +86-18532138899
L18532138899@163.com China 939 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21639 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9220 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3009 60
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32820 60

66575-29-9(Colforsin)Verwandte Suche:


  • 7BETA-ACETOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE
  • 7BETA-ACETOXY-8,13-EPOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE
  • 7BETA-ACETOXY-8,13-EPOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-ENE-11-ONE
  • [3R-(3A,4AB,5B,6B,6AA,10A,10AB,10BA)]-5-(ACETYLOXY)-3-ETHENYLDODECAHYDRO-6,10,10B-TRIHYDROXY-3,4A,7,7,10A-PENTAMETHYL-1H-NAPHTHO[2,1-B]PYRAN-1-ONE
  • 10a-beta,10b-alpha))-10-alph
  • 1-b)pyran-1-one,dodecahydro-5-(acetyloxy)-3-ethenyl-3,4a,7,7,10a-1h-naphtho(
  • pentamethyl-6,10,10b-trihydroxy-,(3r-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,
  • FORSKOLIN FROM COLEUS FORSKOHLII
  • FORSKOLIN, MOLECULAR BIOLOGY REAGENT
  • FORSKOLIN 98+%
  • FORSKOLIN, 99+%
  • Forsklin
  • 1H-Naphtho[2,1-b]pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-
  • Forskolin ForsLean Colforsin HL 362 NSC 357088 NSC 375489
  • BETA-ACETOXY-8,13-EPOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE
  • FORSKOHLIN
  • FORSKOLIN
  • FORSKOLIN, COLEUS FORSKOHLII
  • COLEONOL
  • COLFORSIN
  • (3R,4AR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldod
  • Boforsin
  • (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-Naphtho[2,1-b]pyran-1-one
  • ForsLean
  • HL 362
  • L 75-1362B
  • NSC 35708
  • 7β-acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one
  • Forskolin, Colforsin, Coleonol
  • FORMYL-O-BENZYL-L-SERINE
  • Coleonol, Colforsin
  • (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-Naphtho[2,1-β]pyran-1-one
  • NSC 357088
  • 7SS-ACETOXY-8,13-EPOXY-1ALPHA,6SS,9ALPHA-TRIHYDROXYLABD-14-EN-11-ONE
  • Coleonol, Colforsin, 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one
  • Colforsin, Boforsin
  • [3R-(3alpha,4abeta,5beta,6beta,6aalpha,10alpha,10abeta,10betaalpha)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
  • (3R,6aα)-5β-Acetoxy-3α-ethenyldodecahydro-6β,10α,10bα-trihydroxy-3,4aβ,7,7,10aβ-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
  • 7-Acetoxy-8,13-epoxy-1alpha,6,9alpha-trihydroxylabd-14-en-11-one
  • 7β-Acetoxy-8,23-epoxy-1 α
  • ForskolinColforsin
  • [3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
  • NSC 375489
  • Forskolin (40 mg) (7Beta-acetoxy-8,13-epoxy-1alpha,6Beta,9alpha-trihydroxy-labd-14-en-11-one)
  • Forskolii
  • Coleus forskohlii(Willd.)Briq.
  • Forskolin, 98%, from Coleus forskohlii
  • Forskolin (plant extract)
  • Forskolin ( Coleus Forskohlii extract)
  • Forskolin - Coleonol
  • CS-736
  • Forskolin, Coleus forskohlii - CAS 66575-29-9 - Calbiochem
  • Forskolin >
  • (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl acetate
  • Forskolin, ≥98% (HPLC), powder
  • 2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOL
  • Forskolin supplier in China
  • Coleus Forskolin
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