Ro 67-7476

298690-60-5

CAS-Nr.: 298690-60-5

Englisch Name:: Ro 67-7476

Synonyma:: Ro 67-7476;RO67-7476;RO-67-7476;(2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine;Pyrrolidine, 2-(4-fluorophenyl)-1-[(4-methylphenyl) sulfonyl]-, (2S)-;excitatory postsynaptic potentials,Ro 67-7476,cAMP accumulation,mGluR,neuronal culture,Metabotropic glutamate receptors,Ro 67 7476,inhibit,Ro 677476,traumatic injury,mGluR1,Inhibitor

CBNumber:: CB02561080

Summenformel:: C17H18FNO2S

Molgewicht:: 319.39

MOL-Datei:: 298690-60-5.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 61

Ro 67-7476 Eigenschaften

Siedepunkt:: 452.9±55.0 °C(Predicted)

Dichte: 1.268±0.06 g/cm3(Predicted)

storage temp.: Store at RT

Löslichkeit: DMSO:30.0(Max Conc. mg/mL);93.9(Max Conc. mM)

pka: -5.53±0.40(Predicted)

Aggregatzustand: Powder

Farbe: White to yellow

Sicherheit

Ro 67-7476 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Ro 67-7476 is a positive allosteric modulator of metabotropic glutamate receptor 1 (mGluR1) that enhances glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a (EC₅₀ = 1.74 μM). It is selective for rat mGluR1 over rat mGluR2, mGluR4, and mGluR8 at a concentration of 10 μM. Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5 in the Purkinje cells of rat cerebellar slices. It activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC₅₀ = 163.3 nM).

Verwenden

Ro 67-7476 is a positive allosteric metabotropic mGlu1 receptor modulator.

Ro 67-7476 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Ro 67-7476 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 61)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Nanjing Norris-Pharm Technology Co., Ltd	13901585132	799750417@qq.com	China	8888	55
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58
EnliPharma Technology Co., Ltd	0551-66399836 18955197623	sales@enlipharma.com	China	1874	55
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Shanghai Changyan Chem & Tech Co., Ltd.	021-20242659 18930833303	Sales@changyanchem.cn	China	5011	55
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8014	62
Musechem	+1-800-259-7612	info@musechem.com	United States	4662	60

Ro 67-7476
Pyrrolidine, 2-(4-fluorophenyl)-1-[(4-methylphenyl) sulfonyl]-, (2S)-
(2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine
RO67-7476;RO-67-7476
excitatory postsynaptic potentials,Ro 67-7476,cAMP accumulation,mGluR,neuronal culture,Metabotropic glutamate receptors,Ro 67 7476,inhibit,Ro 677476,traumatic injury,mGluR1,Inhibitor
298690-60-5