Ro 67-7476
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Ro 67-7476 속성
- 끓는 점
- 452.9±55.0 °C(Predicted)
- 밀도
- 1.268±0.06 g/cm3(Predicted)
- 저장 조건
- Store at RT
- 용해도
- DMSO:30.0(Max Conc. mg/mL);93.9(Max Conc. mM)
- 산도 계수 (pKa)
- -5.53±0.40(Predicted)
- 물리적 상태
- 가루
- 색상
- White to yellow
안전
Ro 67-7476 C화학적 특성, 용도, 생산
개요
Ro 67-7476 is a positive allosteric modulator of metabotropic glutamate receptor 1 (mGluR1) that enhances glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a (EC50 = 1.74 μM). It is selective for rat mGluR1 over rat mGluR2, mGluR4, and mGluR8 at a concentration of 10 μM. Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5 in the Purkinje cells of rat cerebellar slices. It activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50 = 163.3 nM).용도
Ro 67-7476 is a positive allosteric metabotropic mGlu1 receptor modulator.Ro 67-7476 준비 용품 및 원자재
원자재
준비 용품
Ro 67-7476 공급 업체
글로벌( 62)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 |
799750417@qq.com | China | 8888 | 55 |
| MedChemexpress LLC | 021-58955995 |
sales@medchemexpress.cn | United States | 4863 | 58 |
| EnliPharma Technology Co., Ltd | 0551-66399836 18955197623 |
sales@enlipharma.com | China | 1874 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 |
info@emmx.com | United States | 8449 | 60 |
| Shanghai Changyan Chem & Tech Co., Ltd. | 021-021-20242659 18930833303 |
order@changyanchem.com | China | 5008 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 |
2853530910@QQ.com | China | 8012 | 62 |
| Musechem | +1-800-259-7612 |
info@musechem.com | United States | 4662 | 60 |