4-BroMo-N-(4-broMophenyl)-3-[[(phenylMethyl)aMino]sulfonyl]benzaMide
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- CAS-Nr.
- 312756-74-4
- Englisch Name:
- 4-BroMo-N-(4-broMophenyl)-3-[[(phenylMethyl)aMino]sulfonyl]benzaMide
- Synonyma:
- RS-1;CS-2312;RS1;RS 1;RAD51-stimulatory compound 1;RAD51-Stimulatory Compound-1, RS-1;RS-1 - RAD51-Stimulatory Compound-1;RAD51,RS1,RS-1,inhibit,Inhibitor,RS 1,CRISPR/Cas9;3-benzylsulfamoyl-4-bromo-N-(4-bromophenyl)benzamide;3-(N-Benzylsulfamoyl)-4-bromo-N-(4-bromophenyl)benzamide;RAD51-Stimulatory Compound-1, RS-1 - CAS 312756-74-4 - Calbiochem
- CBNumber:
- CB02695334
- Summenformel:
- C20H16Br2N2O3S
- Molgewicht:
- 524.23
- MOL-Datei:
- 312756-74-4.mol
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4-BroMo-N-(4-broMophenyl)-3-[[(phenylMethyl)aMino]sulfonyl]benzaMide Eigenschaften
- Dichte
- 1.680±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- Löslichkeit
- DMSO: ≥10mg/mL
- Aggregatzustand
- powder
- pka
- 10.16±0.30(Predicted)
- Farbe
- off-white to light tan
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- InChIKey
- VBOWCZDVEOFGRY-UHFFFAOYSA-N
- CAS Datenbank
- 312756-74-4
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xi |
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| R-Sätze: |
36 |
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| S-Sätze: |
26 |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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4-BroMo-N-(4-broMophenyl)-3-[[(phenylMethyl)aMino]sulfonyl]benzaMide Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
RS-1 is an activator of DNA repair protein RAD51 (K
d = 48-107 for human RAD51 with different cofactors present). It stimulates homologous strand assimilation activity at least 5- to 11-old, enhancing homologous recombination activity of hRAD51. RS-1 is a potent enhancer of CRISPR-mediated genome editing, increasing homology directed repair 3- to 6-fold. It is used to increase CRISPR-mediated knock-in efficiencies
in vitro and
in vivo.
Verwenden
4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide is a stimulant of the human homologous recombination protein RAD51.
Allgemeine Beschreibung
A cell-permeable sulfonamido-benzamide-based allosteric regulator that stimulates DNA binding and recombinase activities of hRAD51 by locking hRAD51 in an active conformation without affecting its active site ATP hydrolysis. Although RS-1 enhances hRAD51 filament formation on ssDNA with or without the cofactor NTP, active filaments and recombinase activity are only induced in the presence of ATP or AMP-PNP, but not with ADP or no cofactors. Shown to promote resistance of primary human neonatal dermal fibroblasts to Cisplatin- (Cat. No.
232120) induced death in a dose-dependent manner. RS-1 is inactive toward related DNA strand exchange proteins scRAD5 and scDMC1 of yeast origin or
E. coli RedA.This HDR (homology-directed repair) enhancer, is shown to significantly increase both Cas9 & TALEN-mediated knock-in efficiencies.
4-BroMo-N-(4-broMophenyl)-3-[[(phenylMethyl)aMino]sulfonyl]benzaMide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-BroMo-N-(4-broMophenyl)-3-[[(phenylMethyl)aMino]sulfonyl]benzaMide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 119)Lieferanten
312756-74-4()Verwandte Suche:
- 4-BroMo-N-(4-broMophenyl)-3-[[(phenylMethyl)aMino]sulfonyl]benzaMide
- RAD51-Stimulatory Compound-1, RS-1
- RAD51-stimulatory compound 1
- RS-1
- CS-2312
- RS1;RS 1
- RS-1 - RAD51-Stimulatory Compound-1
- 3-benzylsulfamoyl-4-bromo-N-(4-bromophenyl)benzamide
- RAD51-Stimulatory Compound-1, RS-1 - CAS 312756-74-4 - Calbiochem
- Benzamide, 4-bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]-
- 3-(N-Benzylsulfamoyl)-4-bromo-N-(4-bromophenyl)benzamide
- RAD51,RS1,RS-1,inhibit,Inhibitor,RS 1,CRISPR/Cas9
- 312756-74-4
- API
- Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
