4-브로모-N-(4-브로모페닐)-3-[[(페닐메틸)아미노]술포닐]벤자미드
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4-브로모-N-(4-브로모페닐)-3-[[(페닐메틸)아미노]술포닐]벤자미드 속성
- 밀도
- 1.680±0.06 g/cm3(Predicted)
- 저장 조건
- room temp
- 용해도
- DMSO: ≥10mg/mL
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 10.16±0.30(Predicted)
- 색상
- 회백색에서 밝은 황갈색
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
- InChIKey
- VBOWCZDVEOFGRY-UHFFFAOYSA-N
- CAS 데이터베이스
- 312756-74-4
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
4-브로모-N-(4-브로모페닐)-3-[[(페닐메틸)아미노]술포닐]벤자미드 C화학적 특성, 용도, 생산
개요
RS-1 is an activator of DNA repair protein RAD51 (Kd = 48-107 for human RAD51 with different cofactors present). It stimulates homologous strand assimilation activity at least 5- to 11-old, enhancing homologous recombination activity of hRAD51. RS-1 is a potent enhancer of CRISPR-mediated genome editing, increasing homology directed repair 3- to 6-fold. It is used to increase CRISPR-mediated knock-in efficiencies in vitro and in vivo.용도
4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide is a stimulant of the human homologous recombination protein RAD51.일반 설명
A cell-permeable sulfonamido-benzamide-based allosteric regulator that stimulates DNA binding and recombinase activities of hRAD51 by locking hRAD51 in an active conformation without affecting its active site ATP hydrolysis. Although RS-1 enhances hRAD51 filament formation on ssDNA with or without the cofactor NTP, active filaments and recombinase activity are only induced in the presence of ATP or AMP-PNP, but not with ADP or no cofactors. Shown to promote resistance of primary human neonatal dermal fibroblasts to Cisplatin- (Cat. No. 232120) induced death in a dose-dependent manner. RS-1 is inactive toward related DNA strand exchange proteins scRAD5 and scDMC1 of yeast origin or E. coli RedA.This HDR (homology-directed repair) enhancer, is shown to significantly increase both Cas9 & TALEN-mediated knock-in efficiencies.4-브로모-N-(4-브로모페닐)-3-[[(페닐메틸)아미노]술포닐]벤자미드 준비 용품 및 원자재
원자재
준비 용품
4-브로모-N-(4-브로모페닐)-3-[[(페닐메틸)아미노]술포닐]벤자미드 공급 업체
글로벌( 116)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29821 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 |
sales@chemhifuture.com | China | 3136 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 |
trendseenbio@gmail.com | China | 11681 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131980 | 58 |
MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 |
1014988033@qq.com | China | 4930 | 55 |
4-브로모-N-(4-브로모페닐)-3-[[(페닐메틸)아미노]술포닐]벤자미드 관련 검색:
xav-939
ME0328
GPI-16552
(GPI16552)
PJ-34
FORMANILIDE
4-Aminodiphenylamine
AZD6738
SGC707
MS023
2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione
3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
Enasidenib
Epacadostat (INCB024360)
indoleaMine-2,3-dioxygenase inhibitor INCB024360
LLY-507
DBeQ