(±)-Tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-on Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
DL-Mevalonolactone is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. It induces depolarization and swelling, decreases NADPH content and aconitase (ACO) activity, and increases malondialdehyde (MDA) production in calcium-loaded rat brain mitochondria. DL-Mevalonolactone reverses decreases in glucose uptake induced by simvastatin (Item Nos.
10010344 |
10010345) in L6 myotubes. Tissue levels and urinary excretion of DL-mevalonolactone are increased in patients with mevalonic aciduria, a disorder characterized by a deficiency in mevalonic kinase activity.
Chemische Eigenschaften
Pale Yellow Oil
Verwenden
A metabolite from endophytes of the medicinal plant Erythrina crista-galli.
Allgemeine Beschreibung
Alkaline hydrolysis of mevalonolactone gives mevalonate. Mevalonate is a precursor of farnesyl and geranylgeranyl pyrophosphates. These pyrophosphates are required for protein prenylation.
läuterung methode
Purify the lactone via the dibenzyl-ethylenediammonium salt (m 124-125o) [Hofmann et al. J Am Chem Soc 79 2316 1957], or by chromatography on paper or on a Dowex-1 (formate) column. [Bloch et al. J Biol Chem 234 2595 1959.] Store it as the N,N'-dibenzylethylenediamine (DBED) salt, or as the lactone in a sealed container at 0o. [Beilstein 18/1 V 19.]
(±)-Tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-on Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
