DL-メバロノラクトン 化学特性,用途語,生産方法
外観
白色/無色~黄色~黄赤色粉末~塊~透明液体
定義
本品は、次の化学式で表されるラクトンである。
溶解性
水、エタノール及びアセトンに溶けやすい。
用途
有機合成原料。
化粧品の成分用途
保湿.湿潤剤
説明
DL-Mevalonolactone is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. It induces depolarization and swelling, decreases NADPH content and aconitase (ACO) activity, and increases malondialdehyde (MDA) production in calcium-loaded rat brain mitochondria. DL-Mevalonolactone reverses decreases in glucose uptake induced by simvastatin (Item Nos.
10010344 |
10010345) in L6 myotubes. Tissue levels and urinary excretion of DL-mevalonolactone are increased in patients with mevalonic aciduria, a disorder characterized by a deficiency in mevalonic kinase activity.
化学的特性
Pale Yellow Oil
使用
A metabolite from endophytes of the medicinal plant Erythrina crista-galli.
一般的な説明
Alkaline hydrolysis of mevalonolactone gives mevalonate. Mevalonate is a precursor of farnesyl and geranylgeranyl pyrophosphates. These pyrophosphates are required for protein prenylation.
純化方法
Purify the lactone via the dibenzyl-ethylenediammonium salt (m 124-125o) [Hofmann et al. J Am Chem Soc 79 2316 1957], or by chromatography on paper or on a Dowex-1 (formate) column. [Bloch et al. J Biol Chem 234 2595 1959.] Store it as the N,N'-dibenzylethylenediamine (DBED) salt, or as the lactone in a sealed container at 0o. [Beilstein 18/1 V 19.]
DL-メバロノラクトン 上流と下流の製品情報
原材料
準備製品