N-Methyl-5H-dibenzo(a,d)cyclohep-ten-5-propanamin Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Protriptyline is a powerful antidepressant, the mechanism of action of which is not
known. It is not a MAO inhibitor and does not stimulate the CNS. It begins to act much
faster and acts much longer than imipramine or amitriptyline. Protriptyline does not possess sedative tranquilizing properties. It is used in clinical conditions for treating severe
depression.
Mechanism of action
Protriptyline exhibits high selectivity for the NE transporter, but with less potency than desipramine. Its
mechanism of action is similar to that of desipramine. Minimal effect on 5-HT reuptake has been observed.
Stoffwechsel
Protriptyline is a dibenzocycloheptriene TCA that differs from the other tricyclics by having an unsaturated
ethylene bridge joining the two aromatic rings and a secondary aminopropyl side chain.
Protriptyline is completely absorbed from the GI tract and slowly eliminated. Metabolism data are limited for protriptyline, but it is most likely to be metabolized via the same
pathways as the other TCAs are. Very little drug is excreted in the feces via the bile.
N-Methyl-5H-dibenzo(a,d)cyclohep-ten-5-propanamin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
