2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate
|
|
- CAS-Nr.
- 164162-36-1
- Englisch Name:
- 2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate
- Synonyma:
- Everolimus Impurity 12;Everolimus intermediate A2(Z);2-(tert-Butydilethylsily) oxyethyl;2-(t-ButyldiMethylsilyl)oxyethyl triflate;2-(tert-Butyldimethylsilyloxy)ethyl triflate;2-(t-Butyldimethylsilyloxy)EthylTrifluoromethanesulfonate;2-(tert-butyldiMethylsilyloxy)ethyl trifluoroMethanesulfonate;2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate;2-{[Dimethyl(2-methyl-2-propanyl)silyl]oxy}ethyl trifluoromethanesulfonate;Trifluoromethanesulfonic acid 2-[[(tert-butyl)dimethylsilyl]oxy]ethyl ester
- CBNumber:
- CB12542770
- Summenformel:
- C9H19F3O4SSi
- Molgewicht:
- 308.39
- MOL-Datei:
- 164162-36-1.mol
|
2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate Eigenschaften
- Siedepunkt:
- 253℃
- Dichte
- 1.172
- Flammpunkt:
- 107℃
Sicherheit
2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate is used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthese
![1.jpg 1.jpg](/NewsImg/2022-01-12/6377759418787685758966332.jpg)
The reaction was carried out under a nitrogen atmosphere. TBS- ethylene glycol prepared as per step 1 (85.10g, 0.48 mol) and 2, 6-Lutidine (84.28ml, 0.72 mol) were stirred in n-heptane (425ml) to give a clear solution which was then cooled to -15 to - 25°C. Trifluoromethanesulfonic anhydride (Tf2O) (99.74 ml, 0.590 mol) was added drop-wise over a period of 45 minutes to the n-heptane solution (white precipitate starts to form immediately) while maintaining the reaction at -15 to -25°C. The reaction mixture was kept at temperature between -15 to -25°C for 2 hours. The precipitate generated was filtered off. The filtrate was then evaporated up to ~2 volumes with respect to TBS-ethyiene glycol (~200 ml).
2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 47)Lieferanten
- Trifluoromethanesulfonic acid 2-[[(tert-butyl)dimethylsilyl]oxy]ethyl ester
- 2-(t-ButyldiMethylsilyl)oxyethyl triflate
- Methanesulfonicacid,1,1,1-trifluoro-,2-[[(1,1-diMethylethyl)diMethylsilyl]oxy]ethylester
- 2-(t-Butyldimethylsilyloxy)EthylTrifluoromethanesulfonate
- 2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate
- 2-(tert-butyldiMethylsilyloxy)ethyl trifluoroMethanesulfonate
- 1,1,1-Trifluoromethanesulfonic acid 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl ester
- 2-{[Dimethyl(2-methyl-2-propanyl)silyl]oxy}ethyl trifluoromethanesulfonate
- Everolimus Impurity 12
- 2-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]ethyl 1,1,1-trifluoromethanesulfonate
- Everolimus intermediate A2(Z)
- 2-(tert-Butydilethylsily) oxyethyl
- 2-(tert-Butyldimethylsilyloxy)ethyl triflate
- 164162-36-1
- C9H19F3O4SSi