BIS(METHYLTHIO)GLIOTOXIN

74149-38-5

CAS-Nr.: 74149-38-5

Englisch Name:: BIS(METHYLTHIO)GLIOTOXIN

Synonyma:: FR-49175;BIS(METHYLTHIO)GLIOTOXIN;Bis(methylthio)gliotoxin (FR-49175);bis-dethio-bis(methylthio)gliotoxin;gliotoxin, bis-dethio-bis(methylthio)-;2,3,5aβ,6,10,10a-Hexahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-3,10aα-bis(methylthio)pyrazino[1,2-a]indole-1,4-dione;(3R)-2,3,5aβ,6,10,10a-Hexahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-3α,10aα-bis(methylthio)pyrazino[1,2-a]indole-1,4-dione;Pyrazino[1,2-a]indole-1,4-dione, 2,3,5a,6,10,10a-hexahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-3,10a-bis(methylthio)-, (3R,5aS,6S,10aR)-

CBNumber:: CB1288191

Summenformel:: C15H20N2O4S2

Molgewicht:: 356.46

MOL-Datei:: 74149-38-5.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 29

BIS(METHYLTHIO)GLIOTOXIN Eigenschaften

Siedepunkt:: 669.6±55.0 °C(Predicted)

Dichte: 1.49±0.1 g/cm3(Predicted)

storage temp.: −20°C

Löslichkeit: Chloroform (Slightly), Methanol (Slightly)

Aggregatzustand: White solid.

pka: 12.69±0.60(Predicted)

Farbe: Off-White to Yellow

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22
S-Sätze:	36
RIDADR	1544
HazardClass	6.1(b)
PackingGroup	III

BIS(METHYLTHIO)GLIOTOXIN Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Bis(methylthio)gliotoxin is a fungal metabolite originally isolated from G. deliquescens that has diverse biological activities. It inhibits PAF- and collagen-induced platelet aggregation in rabbit platelet-rich plasma (IC₅₀s = 8.4 and 84.2 μM, respectively) but has no effect on arachidonic acid- or ADP-induced platelet aggregation (IC₅₀s = >400 μM). Bis(methylthio)gliotoxin inhibits growth of HCT116 colon cancer cells (IC₅₀ = 23.56 μM). It inhibits PAF-induced bronchoconstriction in guinea pigs when administered at a dose of 0.1 mg/kg and is less toxic to mice (LD₅₀ = >500 mg/kg) than gliotoxin . Bis(methylthio)gliotoxin has been used as a serum biomarker in patients infected with invasive aspergillosis.

Enzyminhibitor

This naturally occurring indole derivative (FW = 356.47 g/mol; CAS 74149- 38-5), also known as bis(methylthio)gliotoxin and dimethylgliotoxin, is a platelet-acivating factor (PAF) antagonist that inhibits PAF-induced platelet aggregation. The parent compound, gliotoxin is a dual inhibitor of famesyltransferase and geranylgeranyl-transferase. Bisdethiobis(methylthio)gliotoxin is a minor metabolite of Gliocladium deliquescens, Radiocarbon tracer experiments showed it is formed, apparently irreversibly, from gliotoxin. It has also been synthesized from gliotoxin by reduction and methylation. Bisdethio-bis(methylthio)gliotoxin also binds Cu+ and Ag+ ions.

BIS(METHYLTHIO)GLIOTOXIN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

GLIOTOXIN Methyljodid

Downstream Produkte

BIS(METHYLTHIO)GLIOTOXIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 29)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	China	3000	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
BioBioPha Co., Ltd.	0871-65217109 13211707573;	y.liu@mail.biobiopha.com	China	5654	65
ALB Technology Limited	702-983-3769	sales@albtechnology.com	United States	2993	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9708	58
Shanghai YuanYe Biotechnology Co., Ltd.	021-61312847; 18021002903	3008007409@qq.com	China	27322	60
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Shanghai Bohu Biotechnology Co., LTD	021-57763112 13585886131	3004987436@qq.com	China	9694	58

74149-38-5()Verwandte Suche:

2,5-Dimethyl-piperazin (Gemischder cis- und trans-Isomeren) 1,2,4-Trimethylpiperazin Cyclohexa-1,3-dien Piperazin-2,5-dion 2-Aminoethyldiisopropylamin N,N'-Diisopropylethylendiamin 3,6-Dimethylpiperazin-2,5-dion

gliotoxin, bis-dethio-bis(methylthio)-
(3R)-2,3,5aβ,6,10,10a-Hexahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-3α,10aα-bis(methylthio)pyrazino[1,2-a]indole-1,4-dione
2,3,5aβ,6,10,10a-Hexahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-3,10aα-bis(methylthio)pyrazino[1,2-a]indole-1,4-dione
Bis(methylthio)gliotoxin (FR-49175)
BIS(METHYLTHIO)GLIOTOXIN
FR-49175
bis-dethio-bis(methylthio)gliotoxin
Pyrazino[1,2-a]indole-1,4-dione, 2,3,5a,6,10,10a-hexahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-3,10a-bis(methylthio)-, (3R,5aS,6S,10aR)-
74149-38-5
C15H20N2O4S2