BIS(METHYLTHIO)글리오톡신
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BIS(METHYLTHIO)글리오톡신 속성
- 끓는 점
- 669.6±55.0 °C(Predicted)
- 밀도
- 1.49±0.1 g/cm3(Predicted)
- 저장 조건
- −20°C
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 백색 고체.
- 산도 계수 (pKa)
- 12.69±0.60(Predicted)
- 색상
- 황백색에서 노란색까지
안전
- 위험 및 안전 성명
BIS(METHYLTHIO)글리오톡신 C화학적 특성, 용도, 생산
개요
Bis(methylthio)gliotoxin is a fungal metabolite originally isolated from G. deliquescens that has diverse biological activities. It inhibits PAF- and collagen-induced platelet aggregation in rabbit platelet-rich plasma (IC50s = 8.4 and 84.2 μM, respectively) but has no effect on arachidonic acid- or ADP-induced platelet aggregation (IC50s = >400 μM). Bis(methylthio)gliotoxin inhibits growth of HCT116 colon cancer cells (IC50 = 23.56 μM). It inhibits PAF-induced bronchoconstriction in guinea pigs when administered at a dose of 0.1 mg/kg and is less toxic to mice (LD50 = >500 mg/kg) than gliotoxin . Bis(methylthio)gliotoxin has been used as a serum biomarker in patients infected with invasive aspergillosis.효소 저해제
This naturally occurring indole derivative (FW = 356.47 g/mol; CAS 74149- 38-5), also known as bis(methylthio)gliotoxin and dimethylgliotoxin, is a platelet-acivating factor (PAF) antagonist that inhibits PAF-induced platelet aggregation. The parent compound, gliotoxin is a dual inhibitor of famesyltransferase and geranylgeranyl-transferase. Bisdethiobis(methylthio)gliotoxin is a minor metabolite of Gliocladium deliquescens, Radiocarbon tracer experiments showed it is formed, apparently irreversibly, from gliotoxin. It has also been synthesized from gliotoxin by reduction and methylation. Bisdethio-bis(methylthio)gliotoxin also binds Cu+ and Ag+ ions.BIS(METHYLTHIO)글리오톡신 준비 용품 및 원자재
원자재
준비 용품
BIS(METHYLTHIO)글리오톡신 공급 업체
글로벌( 29)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 |
sales@pioneerbiotech.com | China | 3000 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
BioBioPha Co., Ltd. | 0871-65217109 13211707573; |
y.liu@mail.biobiopha.com | China | 5654 | 65 |
ALB Technology Limited | 702-983-3769 |
sales@albtechnology.com | United States | 2993 | 55 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 |
info@efebio.com | China | 9707 | 58 |
Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 |
3008007409@qq.com | China | 27322 | 60 |
Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 |
sales@glpbio.cn | China | 6870 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 |
sales@chemegen.com | China | 11289 | 58 |
Shanghai Bohu Biotechnology Co., LTD | 021-57763112 13585886131 |
3004987436@qq.com | China | 9694 | 58 |
BIS(METHYLTHIO)글리오톡신 관련 검색:
1,3-시클로헥사디엔 디이소프로필에틸렌디아민 2,5-디메틸피페라진 에테인티올, 2-[비스(1-메틸에틸)아미노]-
N,N'-Diisopropylethylenediamine
CIS-2,5-DIMETHYLPIPERAZINE
GLYCINE ANHYDRIDE
2-Piperazinemethanol
1-ALLYLPIPERAZINE
1,2,4-TRIMETHYLDIETHYLENEDIAMINE
CYCLO(-ALA-ALA)
DL-2-AMINOPROPIONIC ANHYDRIDE
1-Methylpiperazin-2-one
(1,4-DIMETHYL-2-PIPERAZINYL)METHANOL
ACETIC ACID-DIISOPROPYLAMIDE
1-ISOPROPYL-PIPERAZIN-2-ONE
HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE
1-ETHYLPIPERAZIN-2-ONE