(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-prolinmaleat

Enalapril maleate  Struktur
76095-16-4
CAS-Nr.
76095-16-4
Bezeichnung:
(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-prolinmaleat
Englisch Name:
Enalapril maleate
Synonyma:
Olivin;Renitek;Renivace;Enalapril Maleate Salt;(S)-1-((S)-2-((S)-1-ETHOXY-1-OXO-4-PHENYLBUTAN-2-YLAMINO)PROPANOYL)PYRROLIDINE-2-CARBOXYLIC ACID MALEATE;BQL;Pres;Ednyt;Envas;Nuril
CBNumber:
CB1467853
Summenformel:
C24H32N2O9
Molgewicht:
492.52
MOL-Datei:
76095-16-4.mol

(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-prolinmaleat Eigenschaften

Schmelzpunkt:
143-144,5°C
Siedepunkt:
0°C
alpha 
D25 -42.2° (c = 1 in methanol)
Flammpunkt:
0°C
storage temp. 
2-8°C
Löslichkeit
methanol: ≥50 mg/mL, clear, colorless to yellow
Aggregatzustand
powder
pka
pKa1 3.0; pKa2 (25°) 5.4
Farbe
white to off-white
Wasserlöslichkeit
Soluble in water, methanol, and ethanol.
maximale Wellenlänge (λmax)
208nm(MeOH)(lit.)
Merck 
14,3567
BCS Class
1 (LogP), 3 (CLogP)
InChIKey
OYFJQPXVCSSHAI-QFPUQLAESA-N
CAS Datenbank
76095-16-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher Xi,Xn
R-Sätze: 36/37/38-62-63
S-Sätze: 22-24/25-36/37-26
RIDADR  3077
WGK Germany  2
RTECS-Nr. TW3666000
HS Code  29339900
Toxizität LD50 oral in rat: 2973mg/kg

(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-prolinmaleat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Enalapril maleate is the second angiotensin converting enzyme inhibitor to reach the marketplace. Like captopril, the first entry in this area, enalapril is useful in the treatment of hypertension and congestive heart failure. It has a longer effective half-life than captopril, allowing once or twice-daily dosing, and appears to have a somewhat lower incidence of side effects.

Chemische Eigenschaften

White to Off-White Crystalline Powder

Verwenden

Enalapril maleate salt is used as a long-acting ACE inhibitor and antihypertensive, used to study diabetic angiopathy in diabetic rats and inhibition of ACE in hog plasma (I50=1.2nM). ACE inhibitors disturb the enin-angiotensin- aldosterone system. Additional ACE inhibitors include: Enalapril, Enalaprilat dihydrate, Enalaprilat, and Enalapril-d5 Maleate Salt, among others.

Definition

ChEBI: The maleic acid salt of enalapril. It contains one molecule of maleic acid for each molecule of enalapril. Following oral administration, the ethyl ester group of enalapril is hydrolysed to afford the corresponding carboxylic acid, enalaprilat, an angioten in-converting enzyme (ACE) inhibitor. Enalapril is thus a prodrug for enalaprilat (which, unlike enalapril, is not absorbed by mouth), and its maleate is used in the treatment of hypertension and heart failure, for reduction of proteinuria and renal diseas in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients.

Allgemeine Beschreibung

Enalapril maleate, 1-[N[(S)-1-carboxy-3-phenylpropyl]-L-alanyl]-L-proline 1 -ethyl estermaleate (Vasotec), is a long-acting ACE inhibitor. It requiresactivation by hydrolysis of its ethyl ester to form thediacid enalaprilat. Enalapril is devoid of the side effects ofrash and loss of taste seen with captopril. These side effectsare similar to those of the mercapto-containing drugpenicillamine. The absence of the thiol group in enalaprilmaleate may free it from these side effects. The half-life is11 hours.

(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-prolinmaleat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-prolinmaleat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 624)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
APOLLO HEALTHCARE RESOURCES
+6596580999
sales@apollo-healthcare.com.sg Singapore 399 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8811 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12839 58
Wuhan Fortuna Chemical Co., Ltd
+86-027-59207850
info@fortunachem.com China 5978 58
Hebei Dangtong Import and export Co LTD
+86-13910575315 +86-13910575315
admin@hbdangtong.com China 1000 58
Hangzhou ICH Biofarm Co., Ltd
+86-0571-28186870; +undefined8613073685410
sales@ichemie.com China 998 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20287 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
+86-15350851019 +86-15383190639
admin@86-ss.com China 1000 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55

76095-16-4((S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-prolinmaleat)Verwandte Suche:


  • 1-(n-(1-(ethoxycarbonyl)-3-phenylpropyl)-l-alanyl)-l-prolin(s)-l-prolin(z)-2-bu
  • 1-[n-[1-(ethoxycarbonyl)-3-phenylpropyl]-l-alanyl]-l-prolin(s)-l-prolin(z)-2-but
  • mk421maleate
  • n-((s)-1-ethoxycarbonyl-3-phenylpropyl)-l-alanyl-l-proline maleate
  • ENALAPRIL MALLATE
  • Enalapril Maleate USP24,25,EP2000
  • Enalapril maleate BP2000/USP25
  • ENALAPRIL MALEATE, IMP. I (EP): 1H-IMIDAZOLE MM(CRM STANDARD)
  • (s)-1-(n-(1-(ethoxycarbonyl)-3-phenylpropyl)-l-alanyl)-l-prolinemaleate(1:1
  • Biocronil
  • BQL
  • Controlvas
  • Converten
  • Convertin
  • Ednyt
  • Elfonal
  • Enacard
  • Enaladil
  • Enaloc
  • Enapren
  • Enapril
  • Enaprin
  • Enaril
  • Envas
  • Glioten
  • Hipoartel
  • Hytrol
  • Innovace
  • Innovade
  • Inoprilat
  • Invoril
  • Kenopril
  • Lapril
  • Lotrial
  • L-Proline, 1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-, (S)-, (Z)-2-butenedioate (1:1)
  • Minipril
  • Naprilene
  • Naritec
  • Nuril
  • Pres
  • Presil
  • Pressotec
  • Renavace
  • Reniten
  • Repantril
  • Sintec
  • Tenace
  • Unaril
  • Vasopril
  • Xanef
  • ENALAPRIL MALEATE, IMP. D (EP): ETHYL(2S)-2-[(3S,8AS)-3-METHYL-1,4-DIOXO-OCTAHYDROPYRROLO[1,2-ALPHA]PYRAZIN-2-YL]-4-PHENYLBUTANOATE MM(CRM STANDARD)
  • ENALAPRIL MALEATE, MM(CRM STANDARD)
  • ENALAPRIL MALEATE, EP STANDARD
  • ENALAPRIL MALEATE, USP STANDARD
  • ENALAPRIL MALEATE EPE
  • ENALAPRIL MALEATE EPE(CRM STANDARD)
  • ENALAPRIL MALEATE MM
  • ENALAPRIL MALEATE USP
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