ChemicalBook > Produktkatalog >Bio- und Chemieingenieurwesen >Inhibitoren >Eiweiß-Tyrosinkinase (PTK) >Vatalanib Dihydrochloride

Vatalanib Dihydrochloride

212141-51-0

CAS-Nr.: 212141-51-0

Englisch Name:: Vatalanib Dihydrochloride

Synonyma:: PTK/ZK;CS-465;CGP-79787;ZK-222584;CGP-79787D;CGP79787) 2HCl;Vatalinib 2HCl;PTK787 dihydrochloride;Vatalanib 2HCl (PTK787);Vatalanib (PTK787) 2HCl

CBNumber:: CB21176854

Summenformel:: C20H17Cl3N4

Molgewicht:: 419.74

MOL-Datei:: 212141-51-0.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 128

Vatalanib Dihydrochloride Eigenschaften

Schmelzpunkt:: 268-2700C

storage temp.: Inert atmosphere,Store in freezer, under -20°C

Löslichkeit: Soluble in DMSO (up to 20 mg/ml with warming) or in Water (up to 100 mg/ml)

Aggregatzustand: solid

Farbe: White or off-white

Stabilität:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.

CAS Datenbank: 212141-51-0

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

R-Sätze:	36/37/38
S-Sätze:	24/25
HS Code	29333990

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H315	Verursacht Hautreizungen.	Hautreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P302+P352, P321,P332+P313, P362
H319	Verursacht schwere Augenreizung.	Schwere Augenreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P305+P351+P338,P337+P313P
H335	Kann die Atemwege reizen.	Spezifische Zielorgan-Toxizität (einmalige Exposition)	Kategorie 3 (Atemwegsreizung)	Warnung	src="/GHS07.jpg" width="20" height="20" />

Sicherheit

P271	Nur im Freien oder in gut belüfteten Räumen verwenden.
P280	Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

Vatalanib Dihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Vatalanib is an antagonist of the VEGF receptors, inhibiting the receptor tyrosine kinase activities of VEGFR1 (Flt1), VEGFR2 (KDR), and VEGFR3 (Flt4) with IC₅₀ values of 77, 37, and 190 nM, respectively. It less potently inhibits PDGF and c-Kit (IC₅₀ = 600 and 700 nM) and has no effect on a large panel of additional kinases. Vatalanib completely blocks retinal neovascularization in oxygen-induced ischemic retinopathy in mice, suggesting its use in diabetic retinopathy and other diseases featuring aberrant vascular development.

Chemische Eigenschaften

White to Off-White Crystalline Powder

Verwenden

Vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor. Antineoplastic.

Vatalanib Dihydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Vatalanib Dihydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 128)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29882	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22883	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	China	52849	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38632	58

212141-51-0()Verwandte Suche:

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CGP-79787 Dihydrochlorid
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Vatalanib Dihydrochloride
CGP-79787 Dihydrochloride
Vatalanib 2hcl((ZK-222584,PTK 787)
Vatalanib dihydrochloride (PTK787)
CGP-79787
CGP-79787D
PTK/ZK
ZK-222584
CGP-79787, PTK 787, ZK222584
N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride
ZK 222584 (cpg-79787) 2HCl
Vatalanib 2HCl (PTK787)
Vatalanib (PTK787) 2HCl
Vatalanib (hydrochloride)
Vatalanib dihydrochloride(2HCL)
Vatalanib (PTK787) diHydrochloride
CS-465
ZK-222584 dihydrochloride
CGP-797870 dihydrochloride
PTK787 dihydrochloride
Vatalanib Dihydrochloride USP/EP/BP
1-Phthalazinamine,N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-, hydrochloride (1:2)
CGP79787) 2HCl
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212141-51-0
C20H17Cl3N4
C20H15ClN42HCl
C20H15Cl2N42HCl
C20H15ClN42ClH
Heterocycles
Tyrosine Kinase Inhibitors
Antineoplastic
Intermediates & Fine Chemicals
Pharmaceuticals
Inhibitors