AZD-3965

733809-45-5

CAS-Nr.: 733809-45-5

Englisch Name:: AZD-3965

Synonyma:: AZD-3965;(S)-5-(4-hydroxy-4-methylisoxazolidine-2-carbonyl)-1-isopropyl-3-methyl-6-((3-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione;5-[[(4S)-4-Hydroxy-4-methyl-2-isoxazolidinyl]carbonyl]-3-methyl-1-(1-methylethyl)-6-[[3-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione;Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5-[[(4S)-4-hydroxy-4-methyl-2-isoxazolidinyl]carbonyl]-3-methyl-1-(1-methylethyl)-6-[[3-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-

CBNumber:: CB22731018

Summenformel:: C21H24F3N5O5S

Molgewicht:: 515.51

MOL-Datei:: 733809-45-5.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 47

AZD-3965 Eigenschaften

Schmelzpunkt:: >140°C (dec.)

Siedepunkt:: 723.1±70.0 °C(Predicted)

Dichte: 1.483±0.06 g/cm3(Predicted)

storage temp.: -20°C, Inert atmosphere

Löslichkeit: DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)

Aggregatzustand: Solid

pka: 10.92±0.50(Predicted)

Farbe: Off-White to Pale Yellow

Sicherheit

AZD-3965 Chemische Eigenschaften,Einsatz,Produktion Methoden

Enzyminhibitor

This orally bioavailable MCT1 inhibitor (FW = 515.51 g/mol; CASs = 733809-45-5 and 1448671-31-5), also named (S)-5-(4-hydroxy-4- methylisoxazolidine-2-carbonyl)-1-isopropyl-3-methyl-6-((3-methyl-5-(tri fluoromethyl)-1H-pyrazol-4-yl)methyl)-thieno[2,3-d]pyrimidine-2,4(1H, 3H) -dione, selectively targets the Monocarboxylate Transporter-1 (IC50 = 1.6 nM) and is ~6x less active toward MCT2. AZD3965 does not inhibit MCT4, even at 10 μM. MCT1 and MCT4 are primarily involved in lactate transport, targeting highly glycolytic cancer cells, especially those that are hypoxic. The latter property suggests that the combined use with a vascular-disrupting anticancer agent (such as combrestatin) may improve the inhibitory action of AZD-3965 against cancer cells.

AZD-3965 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

AZD-3965 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 47)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2922	55
Shanghai YuanQi Biotechnology Co., Ltd.	+86-2332782371 +86-18120098618	sales@adobechem.com	China	1250	50
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	8012	62
Shanghai Biopharmaleader Co., Ltd.	+86 18721201413	sales@biopharmaleader.com	China	1720	58
Changzhou Chenhong Biotechnology Co., Ltd.	0519-85788828 13775037613	sales@chemrenpharm.com	China	3600	58
Shanghai Zeye Biotechnology Co., Ltd.	021-61998551 13122364865	sale1@shzysw.net	China	9772	58
ShangHai ChuanQian Chemcial Technique Centre	15869524721	3525679403@qq.com	China	3983	58
Shanghai tingchong biology science and technology co., ltd	18964309092 18964309092	2769493375@qq.com	China	2634	58
Hubei Kele Fine Chemical Co., Ltd	027-59101668 19945030958	2881924765@qq.com	China	8140	58

AZD-3965
5-[[(4S)-4-Hydroxy-4-methyl-2-isoxazolidinyl]carbonyl]-3-methyl-1-(1-methylethyl)-6-[[3-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
(S)-5-(4-hydroxy-4-methylisoxazolidine-2-carbonyl)-1-isopropyl-3-methyl-6-((3-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5-[[(4S)-4-hydroxy-4-methyl-2-isoxazolidinyl]carbonyl]-3-methyl-1-(1-methylethyl)-6-[[3-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-
733809-45-5
C21H24F3N5O5S