AZD-3965
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AZD-3965 속성
- 녹는점
- >140°C (dec.)
- 끓는 점
- 723.1±70.0 °C(Predicted)
- 밀도
- 1.483±0.06 g/cm3(Predicted)
- 저장 조건
- -20°C, Inert atmosphere
- 용해도
- DMSO(약간 용해됨), 에탄올(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 10.92±0.50(Predicted)
- 색상
- 황백색에서 연한 노란색
안전
AZD-3965 C화학적 특성, 용도, 생산
효소 저해제
This orally bioavailable MCT1 inhibitor (FW = 515.51 g/mol; CASs = 733809-45-5 and 1448671-31-5), also named (S)-5-(4-hydroxy-4- methylisoxazolidine-2-carbonyl)-1-isopropyl-3-methyl-6-((3-methyl-5-(tri fluoromethyl)-1H-pyrazol-4-yl)methyl)-thieno[2,3-d]pyrimidine-2,4(1H, 3H) -dione, selectively targets the Monocarboxylate Transporter-1 (IC50 = 1.6 nM) and is ~6x less active toward MCT2. AZD3965 does not inhibit MCT4, even at 10 μM. MCT1 and MCT4 are primarily involved in lactate transport, targeting highly glycolytic cancer cells, especially those that are hypoxic. The latter property suggests that the combined use with a vascular-disrupting anticancer agent (such as combrestatin) may improve the inhibitory action of AZD-3965 against cancer cells.AZD-3965 준비 용품 및 원자재
원자재
준비 용품
AZD-3965 공급 업체
글로벌( 47)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 |
masar@topule.com | China | 8474 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | |
sales@boylechem.com | China | 2923 | 55 |
| Shanghai YuanQi Biotechnology Co., Ltd. | +86-2332782371 +86-18120098618 |
sales@adobechem.com | China | 1250 | 50 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 |
2853530910@QQ.com | China | 8014 | 62 |
| Shanghai Biopharmaleader Co., Ltd. | +86 18721201413 |
sales@biopharmaleader.com | China | 1720 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | 0519-85788828 13775037613 |
sales@chemrenpharm.com | China | 3600 | 58 |
| Shanghai Zeye Biotechnology Co., Ltd. | 021-61998551 13122364865 |
sale1@shzysw.net | China | 9772 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 |
3525679403@qq.com | China | 3714 | 58 |
| Shanghai tingchong biology science and technology co., ltd | 18964309092 18964309092 |
2769493375@qq.com | China | 2635 | 58 |
| Hubei Kele Fine Chemical Co., Ltd | 027-59101668 19945030958 |
2881924765@qq.com | China | 7969 | 58 |