ALMOTRIPTAN

ALMOTRIPTAN Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Almotriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT_1B and 5-HT_1D (IC₅₀s = 12 and 13 nM, respectively, in a radioligand binding assay). It is selective for human 5-HT_1B and 5-HT_1D receptors over rat 5-HT_1A and human 5-HT_2A and 5-HT₄ receptors (IC₅₀s = 0.85, 25.1, and 140 μM, respectively). Almotriptan induces contractions in isolated canine saphenous veins (EC₅₀ = 394 nM) but not isolated rabbit renal or mesenteric arteries. It increases carotid vascular resistance in anesthetized cats (ED₁₀₀ = 11 μg/kg, i.v.) without increasing blood pressure or heart rate. Formulations containing almotriptan have been used in the treatment of migraine headaches.

Chemische Eigenschaften

Pale Yellow Solid

Verwenden

Almotriptan is a serotonin 5HT1B /1D-receptor agonist used for treatment of migraine.

Definition

ChEBI: The malate salt of almotriptan.

Allgemeine Beschreibung

Almotriptan, marketed in 2000, has the highest oralbioavailability among all triptans. It is metabolizedby both MAO-A and CYP3A4, thus has a more favorableside effects profile when compared with sumatriptan.However, it is only available in a 12.5 mg tablet form.

ALMOTRIPTAN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

ALMOTRIPTAN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	10977	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29894	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58

181183-52-8()Verwandte Suche:

---

• BUTANEDIOIC ACID, HYDROXY-, COMPD WITH 1-[[[3-[2-(DIMETHYLAMINO)ETHYL]-1H-INDOL-5-YL]METHYL]SULFONYL]PYRROLIDINE
• ALMOTRIPTAN MALATE
• AlmotriptanMaleate
• 1-[[[2-(Dimethyl-amino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine Malate
• 1-[[3-(2-dimethylaminoethyl)-5-indolyl]methanesulphonyl]pyrrolidine Malate
• LAS-31416 Malate
• Almotriptan
• 1-[[[3-[2-(dimeth
• 2-Hydroxy-butanedioic acid, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine (1:1)
• hydroxy-Butanedioic acid, compd.with 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine(1:1)(9CI)
• Almotriptan Malate (200 mg)
• AlMotriptan Malate See: A575201
• AlMotriptan Malate (Axert)
• N,N-Dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethanamine
• N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine,compd. with 2-hydroxy-butanedioic acid
• Amotriptan malate
• Almogran
• Axert
• AXERT; ALMOGRAN; PNU-180638;PNU 180638
• PNU 180638
• PNU-180638
• Almotriptan Malate(PNU180638)
• 3-[2-(Dimethylamino)ethyl]-5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indole Malate
• ALMOTRIPTAN USP/EP/BP
• Almotriptan Malate (LAS 31416)
• Almotriptan MaleateQ: What is Almotriptan Maleate Q: What is the CAS Number of Almotriptan Maleate Q: What is the storage condition of Almotriptan Maleate Q: What are the applications of Almotriptan Maleate
• Almotriptan Malate (1013512)
• Butanedioic acid, 2-hydroxy-, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine (1:1)
• 181183-52-8
• C17H25N3O2SC4H6O5
• C21H31N3O7S
• Inhibitors
• API
• Pharmaceutical material and intermeidates
• Intermediates & Fine Chemicals
• Neurochemicals
• Pharmaceuticals