9,10-Secoergosta-5(Z),7(E),10(19)-trien-3β-ol

VitaMin D4 Struktur
511-28-4
CAS-Nr.
511-28-4
Bezeichnung:
9,10-Secoergosta-5(Z),7(E),10(19)-trien-3β-ol
Englisch Name:
VitaMin D4
Synonyma:
VITAMIN D;COLECALCIFEROL;CALCIOL;RACUMIN D;Duphafral;Vtamin D4;vitamin D4;VITAMINE D4;OLEOVITAMIN D3;CHOLECALCIFEROLUM
CBNumber:
CB3104866
Summenformel:
C28H46O
Molgewicht:
398.66
MOL-Datei:
511-28-4.mol

9,10-Secoergosta-5(Z),7(E),10(19)-trien-3β-ol Eigenschaften

Schmelzpunkt:
83-86 °C(lit.)
alpha 
D18 +89.3° (c = 0.47 in acetone)
Siedepunkt:
504.9±29.0 °C(Predicted)
Dichte
0.96
storage temp. 
2-8°C
Löslichkeit
Soluble in Chloroform
Aggregatzustand
Powder
pka
14.74±0.20(Predicted)
Farbe
Off-white to light yellow
Stabilität:
Hygroscopic, Temperature Sensitive
CAS Datenbank
511-28-4(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T+
R-Sätze: 24/25-26-48/25
S-Sätze: 28-36/37
RIDADR  UN 2811 6.1/PG 2
WGK Germany  2
RTECS-Nr. VS2900000
8-10-23
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H330 Lebensgefahr bei Einatmen. Akute Toxizität inhalativ Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H372 Schädigt bei Hautkontakt und Verschlucken die Organe bei längerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizität (wiederholte Exposition) Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" /> P260, P264, P270, P314, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P314 Bei Unwohlsein ärztlichen Rat einholen / ärztliche Hilfe hinzuziehen.

9,10-Secoergosta-5(Z),7(E),10(19)-trien-3β-ol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R24/25:Giftig bei Berührung mit der Haut und beim Verschlucken.
R26:Sehr giftig beim Einatmen.
R48/25:Giftig: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Verschlucken.

S-Sätze Betriebsanweisung:

S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.

Beschreibung

Derived from cholesterol, vitamin D is biosynthesized from its prohormone cholecalciferol (D3), the product of solar ultraviolet irradiation of 7-dehydrocholesterol in the skin. In 1966, it was first recognized that vitamin D must undergo activation via two oxidative metabolic steps. The first oxidation to 25-hydroxycholecalciferol (25(OH)D3: calcifediol; Calderol) occurs in the endoplasmic reticulum of the liver and is catalyzed by vitamin D 25-hydroxylase. This activation step is not regulated by plasma calcium concentrations. The major circulating form (10–80 μg/mL) is 25(OH)D3, which also is the primary storage form of vitamin D.

Chemische Eigenschaften

Pale Yellow Oil

Verwenden

Vitamin D4 is the active analogue of Vitamin D.

Biologische Funktion

Sterol-specific cytoplasmic receptor proteins (vitamin D receptor) mediate the biological action of vitamin D. The active hormone is transported from the cytoplasm to the nucleus via the vitamin D receptor, and as a result of the interaction of the hormone with target genes, a variety of proteins are produced that stimulate the transport of calcium in each of the target tissues Active vitamin D works in concert with PTH to enhance active intestinal absorption of calcium, to stimulate bone resorption, and to prohibit renal excretion of calcium. If serum calcium or 1,25-calcitriol concentrations are elevated, then vitamin D 24-hydroxylase (in renal mitochondria) is activated to oxidize 25(OH)D3 to inactive 24,25-dihydroxy-cholecalciferol and to further oxidize active vitamin D to the inactive 1,24,25-trihydroxylated derivative. Both the 1,24,25-trihydroxylated and the 24,25-dihydroxylated products have been found to suppress PT H secretion as well. The biosynthesis of vitamin D is tightly regulated based on the serum concentrations of calcium, phosphate, PTH, and active vitamin D.

9,10-Secoergosta-5(Z),7(E),10(19)-trien-3β-ol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


9,10-Secoergosta-5(Z),7(E),10(19)-trien-3β-ol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 174)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5893 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21635 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29885 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14332 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32077 58
Shanxi Xuanran Import and Export Trade Co., Ltd.
+8617735180244
mike_yan@xuanranglobal.com CHINA 4017 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 22883 58
Finetech Industry Limited
+86-27-87465837 +8618971612321
info@finetechnology-ind.com China 9640 58
Baoji Guokang Healthchem co.,ltd
+8615604608665 15604608665
dominicguo@gk-bio.com CHINA 9414 58

511-28-4(9,10-Secoergosta-5(Z),7(E),10(19)-trien-3β-ol)Verwandte Suche:


  • RACUMIN D
  • OLEOVITAMIN D3
  • ANTI-RACHITIC VITAMIN
  • CHOLECALCIFEROLUM
  • 22-Dihydroergocalciferol
  • Cyclohexanol, 4-methylene-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,4S)-1,4,5-trimethylhexyl]-4H-inden-4-ylidene]ethylidene]-, (1S,3Z)-
  • (3S,5Z,7E)-9,10-Secoergosta-5,7,10-trien-3-ol
  • VITAMINE D4
  • CHOLECALCIFEROL (VITAMIN D3) USP(CRM STANDARD)
  • (1S,3Z)-4-Methylene-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-Methyl-1-[(1R,4S)-1,4,5-triMethylhexyl]-4H-inden-4-ylidene]ethylidene]cyclohexanol
  • (3β,5Z,7E)-9,10-Secoergosta-5,7,10(19)-trien-3-ol
  • 22,23-Dihydroercalciol
  • 24S-Methylcalciol
  • ACTIVATED 7-DEHYDROCHOLESTEROL
  • 9,10-SECOCHOLESTA-5,7,19(19)-TRIEN-3-OL-(3B,5Z,7E)-CHOLECIFEROL
  • 7-DEHYDROCHOLESTEROL ACTIVATED
  • 5,7,10(19)-CHOLESTATRIEN-3BETA-OL-9,10-SECO
  • 9,10-secoergosta-5(Z),7(E),10(19)-trien-3beta-ol
  • Duphafral
  • 22,23-DihydrovitaminD2,22,23-Dihydroergocalciferol
  • VitamineD4Discontinued
  • VITAMIN D3(CHOLECALCIFEROL)(RG)
  • VITAMIN D3(CHOLECALCIFEROL)(USP)(SH)
  • Chdecalciferolchdes terol
  • D(cholecalciferol)
  • (3β,5Z,7E)-24-Methyl-9,10-secocholesta-5,7,10(19)-trien-3-ol
  • 22,23-Dihydroergocalciferol
  • 22:23-Dihydrovitamin D2
  • vitamin D4
  • Ergocalciferol EP Impurity G
  • Vitamin D9 Injection
  • Ergocalciferol Impurity 7(Ergocalciferol EP Impurity G)
  • (S,Z)-3-((E)-2-((1R,3aS,7aR)-1-((2R,5S)-5,6-dimethylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexanol
  • VitaMin D4 USP/EP/BP
  • VITAMIN D
  • CALCIOL
  • COLECALCIFEROL
  • Calcipotriol Impurity 19
  • Vtamin D4
  • Ergocalciferol Impurity 7
  • 511-28-4
  • Gene Regulation
  • Complex Molecules
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  • Asymmetric Synthesis
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