N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)

17328-16-4

CAS-Nr.: 17328-16-4

Englisch Name:: N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)

Synonyma:: TC-E 5003;N'-(Sulfonyldi-4;TC-E 5003 (NSC-30176);1-phenylene)bis(2-chloroacetamide);Bis[4-(chloroacetylamino)phenyl] sulfone;4',4'''-Sulfonylbis(α-chloroacetanilide);N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide);N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide);N,N'-[Sulfonylbis(4,1-phenylene)]bis(2-chloroacetamide);Acetamide, N,N'-(sulfonyldi-4,1-phenylene)bis[2-chloro-

CBNumber:: CB32217920

Summenformel:: C16H14Cl2N2O4S

Molgewicht:: 401.26

MOL-Datei:: 17328-16-4.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 65

N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Eigenschaften

Schmelzpunkt:: 191-192 °C

Siedepunkt:: 704.2±60.0 °C(Predicted)

Dichte: 1.504±0.06 g/cm3(Predicted)

storage temp.: -20°C (des.)

Löslichkeit: Soluble in DMSO (up to 50 mg/ml).

Aggregatzustand: solid

pka: 11.56±0.70(Predicted)

Farbe: Brown

Stabilität:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

Sicherheit

N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

TC-E 5003 is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC₅₀ = 1.5 μM for human PRMT1 in a methylation assay). It is selective for PRMT1 over PRMT4/CARM1 and SET7/9 methyltransferases, with less than 5% inhibition at a concentration of 50 μM for SET7/9. TC-E 5003 inhibits growth of MCF-7a breast cancer and LNCaP prostate cancer cells (GI₅₀s = 1.97 and 4.49 μM, respectively) and decreases androgen-dependent gene transcription in vitro. TC-E 5003 (80 mg/kg) also has antimalarial properties and eradicates P. berghei in mice.

Verwenden

NSC 30176 is a inhibitor of human PRMT1, it is selective for PRMT1 over the arginine methyltransferase CARM1 and the lysine methyltransferase Set7/9.

N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 65)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	17322	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10032	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30240	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33338	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58

17328-16-4()Verwandte Suche:

(1R, 2S 3R, 6S)-1,2-Dimethyl-3,6-epoxycyclohexan-1,2-dicarbon-säureanhydrid

4',4'''-Sulfonylbis(α-chloroacetanilide)
Bis[4-(chloroacetylamino)phenyl] sulfone
N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)
TC-E 5003
N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide)
N'-(Sulfonyldi-4
1-phenylene)bis(2-chloroacetamide)
TC-E 5003 (NSC-30176)
N,N'-[Sulfonylbis(4,1-phenylene)]bis(2-chloroacetamide)
Inhibitor,TC-E 5003,hPRMT1,inhibit,Histone Methyltransferase,TLR4 signaling,anti-inflammatory,TCE 5003,TC E 5003
Acetamide, N,N'-(sulfonyldi-4,1-phenylene)bis[2-chloro-
N,N'-(Sulfonylbis(4,1-phenylene))bis(2-chloroacetamide)
17328-16-4