N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)
![N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Structure](CAS/GIF/17328-16-4.gif)
- CAS No.
- 17328-16-4
- Chemical Name:
- N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)
- Synonyms
- TC-E 5003;N'-(Sulfonyldi-4;TC-E 5003 (NSC-30176);TC-E 5003, 10 mM in DMSO;1-phenylene)bis(2-chloroacetamide);4',4'-SULFONYLBIS(2-CHLOROACETANILIDE);4',4'-SULFONYLBIS(2-CHLOROACETANILIDE);Bis[4-(chloroacetylamino)phenyl] sulfone;4',4'''-Sulfonylbis(α-chloroacetanilide);N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide)
- CBNumber:
- CB32217920
- Molecular Formula:
- C16H14Cl2N2O4S
- Molecular Weight:
- 401.26
- MDL Number:
- MFCD00028183
- MOL File:
- 17328-16-4.mol
| Melting point | 191-192 °C |
|---|---|
| Boiling point | 704.2±60.0 °C(Predicted) |
| Density | 1.504±0.06 g/cm3(Predicted) |
| storage temp. | -20°C (des.) |
| solubility | Soluble in DMSO (up to 50 mg/ml). |
| form | solid |
| pka | 11.56±0.70(Predicted) |
| color | Brown |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S718114 | 4'',4''''-SULFONYLBIS(2-CHLOROACETANILIDE) AldrichCPR | 17328-16-4 | 5MG | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 17718 | TC-E 5003 ≥95% | 17328-16-4 | 25mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 17718 | TC-E 5003 ≥95% | 17328-16-4 | 50mg | $70 | 2024-03-01 | Buy |
| Cayman Chemical | 17718 | TC-E 5003 ≥98% | 17328-16-4 | 500mg | $384 | 2024-03-01 | Buy |
| Cayman Chemical | 17718 | TC-E 5003 ≥95% | 17328-16-4 | 100mg | $130 | 2024-03-01 | Buy |
N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Chemical Properties,Uses,Production
Description
TC-E 5003 is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 1.5 μM for human PRMT1 in a methylation assay). It is selective for PRMT1 over PRMT4/CARM1 and SET7/9 methyltransferases, with less than 5% inhibition at a concentration of 50 μM for SET7/9. TC-E 5003 inhibits growth of MCF-7a breast cancer and LNCaP prostate cancer cells (GI50s = 1.97 and 4.49 μM, respectively) and decreases androgen-dependent gene transcription in vitro. TC-E 5003 (80 mg/kg) also has antimalarial properties and eradicates P. berghei in mice.
Uses
NSC 30176 is a inhibitor of human PRMT1, it is selective for PRMT1 over the arginine methyltransferase CARM1 and the lysine methyltransferase Set7/9.
in vivo
TC-E 5003 (0.5-2.0 mg, s.c., a single dose for 28 days) has an excellent tumor-suppressing effect in A549 tumor xenograft ICR mouse models [3].
| Animal Model: | A549 tumor xenograft ICR mouse model[3] |
| Dosage: | 0.5-2.0 mg |
| Administration: | s.c., a single dose for 28 days |
| Result: | Achieved better antitumor effect in combination with INEI system in A549 tumor xenograft ICR mouse model. |
IC 50
PRMT1
References
1) Bissinger?et al. (2011),?Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methytransferase hPRMT1; Bioorg. Med. Chem.,?19?3717
N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19825 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32202 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
