Paraflutizid

paraflutizide Struktur
1580-83-2
CAS-Nr.
1580-83-2
Bezeichnung:
Paraflutizid
Englisch Name:
paraflutizide
Synonyma:
LD-3612;Paraflutizida;paraflutizide;6-Chloro-3-(p-fluorobenzyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;6-chloro-3-(4-fluorobenzyl)-1,1-diketo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide;6-chloro-3-[(4-fluorophenyl)methyl]-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide;2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[(4-fluorophenyl)methyl]-3,4-dihydro-, 1,1-dioxide
CBNumber:
CB3875049
Summenformel:
C14H13ClFN3O4S2
Molgewicht:
405.85
MOL-Datei:
1580-83-2.mol

Paraflutizid Eigenschaften

Schmelzpunkt:
238-240°
Siedepunkt:
636.2±65.0 °C(Predicted)
Dichte
1.571±0.06 g/cm3(Predicted)
pka
8.66±0.40(Predicted)

Sicherheit

Toxizität LD50 oral in mouse: > 10gm/kg

Paraflutizid Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Paraflutizide, Shanghai Lansheng

Manufacturing Process

A mixture of 5.0 g (0.0357 g/mol) of ρ-fluorophenylethyl alcohol, 2.0 g (0.007 g/mol) of 5-chloro-2,4-disulphamylaniline, 2.0 g (0.0068 g/mol) of potassium bichromate and 15 ml of concentrated hydrochloric acid (0.176 g/mol) and 25 ml of water is heated under reflux for 1 h. The mixture is allowed to cool, and 15 ml of ether are added to separate the excess of ρ-fluorophenylethyl alcohol. The aqueous layer is decanted and frozen for 2 h and the precipitate is separated, washed with water and dried in vacuum over phosphoric anhydride. There are collected 1.35 g (yield 47.5%) of the 1,1-dioxide of 3-ρfluorophenyl-methyl-7-sulphamyl-6-chloro-3,4-dihydrobenzo-1,2,4-thiadiazine, which when recrystallised from 30 ml of 50% alcohol on "Norit" active carbon takes the form of a white crystalline substance, melting point is 239°C.

Therapeutic Function

Diuretic

Paraflutizid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Paraflutizid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 9)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32063 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207
sales@molcore.com China 49734 58
TargetMol Chemicals Inc.
+8613564774135
zijue.cai@tsbiochem.com United States 19863 58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd 15229059051
1027@dideu.com China 9982 58
TargetMol Chemicals Inc. 4008200310
marketing@tsbiochem.com China 24648 58

1580-83-2(Paraflutizid)Verwandte Suche:


  • paraflutizide
  • 6-Chloro-3-(p-fluorobenzyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • LD-3612
  • 6-chloro-3-(4-fluorobenzyl)-1,1-diketo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
  • 6-chloro-3-[(4-fluorophenyl)methyl]-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[(4-fluorophenyl)methyl]-3,4-dihydro-, 1,1-dioxide
  • Paraflutizida
  • 1580-83-2
  • C14H13ClFN3O4S2
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