Aurora Kinase Inhibitor III

879127-16-9

CAS-Nr.: 879127-16-9

Englisch Name:: Aurora Kinase Inhibitor III

Synonyma:: AKI-7169;Aurora Kinase Inhibitor 3;Aurora Kinase Inhibitor III;AKI-7169(Aurora Kinase Inhibitor III);Aurora kinase inhibitor-3, 10 mM in DMSO;Aurora Kinase Inhibitor III - CAS 879127-16-9 - Calbiochem;N-[3-[[4-[3-(trifluoromethyl)anilino]pyrimidin-2-yl]amino]phenyl]cyclopropanecarboxamide;N-(3-((4-((3-(Trifluoromethyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)cyclopropanecarboxamide;Cyclopropanecarboxamide, N-[3-[[4-[[3-(trifluoromethyl)phenyl]amino]-2-pyrimidinyl]amino]phenyl]-;Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide

CBNumber:: CB42098016

Summenformel:: C21H18F3N5O

Molgewicht:: 413.4

MOL-Datei:: 879127-16-9.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 65

Aurora Kinase Inhibitor III Eigenschaften

Dichte: 1.456±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

Löslichkeit: H2O: <2mg/mL

pka: 14.51±0.70(Predicted)

Aggregatzustand: White solid

Farbe: white

Wasserlöslichkeit: H2O: <2mg/mL
DMSO: >7mg/mL

InChI: 1S/C21H18F3N5O/c22-21(23,24)14-3-1-4-15(11-14)26-18-9-10-25-20(29-18)28-17-6-2-5-16(12-17)27-19(30)13-7-8-13/h1-6,9-13H,7-8H2,(H,27,30)(H2,25,26,28,29)

InChIKey: RDTDWGQDFJPTPD-UHFFFAOYSA-N

SMILES: FC(F)(F)c1cccc(Nc2ccnc(Nc3cccc(NC(=O)C4CC4)c3)n2)c1

Sicherheit

WGK Germany	3
Speicherklasse	13 - Non Combustible Solids

Aurora Kinase Inhibitor III Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

A cell-permeable 2,4-dianilinopyrimidine compound that acts as an ATP-competitive, potent, but non-selective inhibitor of Aurora A (IC₅₀ = 42 nM). At higher concentrations, also inhibits the activities of other kinases, such as Lck, Bmx, IGF-1R, and Syk (IC₅₀ = 131, 386, 591, and 887 nM, respectively).

Biochem/physiol Actions

Target IC50: 42 nM against Aurora A; 131, 386, 591, and 887 nM, against Lck, Bmx, IGF-1R, and Syk , respectively

Aurora Kinase Inhibitor III Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Aurora Kinase Inhibitor III Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 65)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39040	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	8614	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
NANJING YINGWEN BIOTECHNOLOGY CO LTD	+8613382787392	sales@aeechem.com	China	10000	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	12952	65

Aurora Kinase Inhibitor III
Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide
N-[3-[[4-[3-(trifluoromethyl)anilino]pyrimidin-2-yl]amino]phenyl]cyclopropanecarboxamide
AKI-7169
Aurora Kinase Inhibitor III - CAS 879127-16-9 - Calbiochem
Aurora Kinase Inhibitor 3
Cyclopropanecarboxamide, N-[3-[[4-[[3-(trifluoromethyl)phenyl]amino]-2-pyrimidinyl]amino]phenyl]-
Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide >=98% (HPLC), solid
AKI-7169(Aurora Kinase Inhibitor III)
N-(3-((4-((3-(Trifluoromethyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)cyclopropanecarboxamide
Aurora Kinase,Aurora kinase inhibitor 3,Aurora kinase inhibitor3,Inhibitor,Aurora kinase inhibitor-3,inhibit
Aurora kinase inhibitor-3, 10 mM in DMSO
879127-16-9